GBA-associated PD: chances and obstacles for targeted treatment strategies

Günter Höglinger, Claudia Schulte, Wolfgang H. Jost, Alexander Storch, Dirk Woitalla, Rejko Krüger, Björn Falkenburger, Kathrin Brockmann*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Given the clear role of GBA in the pathogenesis of Parkinson’s disease (PD) and its impact on phenotypical characteristics, this review provides an overview of the current knowledge of GBA-associated PD with a special focus on clinical trajectories and the underlying pathological mechanisms. Importantly, differences and characteristics based on mutation severity are recognized, and current as well as potential future treatment options are discussed. These findings will inform future strategies for patient stratification and cohort enrichment as well as suitable outcome measures when designing clinical trials.

Original languageEnglish
Pages (from-to)1219-1233
Number of pages15
JournalJournal of Neural Transmission
Volume129
Issue number9
Early online date30 May 2022
DOIs
Publication statusPublished - Sep 2022

Keywords

  • GBA
  • Lysosomal
  • PD
  • α-Synuclein

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