Fusion proteins comprising a cytokine and scaffold protein

Jan Steyaert; Els Pardon; Alexandre Wohlkönig; Valentina Kalichuk; Wim Vranken; Tomasz Uchanski; Andy Chevigné; Martyna Szpakowska

Fusion proteins comprising a cytokine and scaffold protein

Jan Steyaert (Inventor), Els Pardon (Inventor), Alexandre Wohlkönig (Inventor), Valentina Kalichuk (Inventor), Wim Vranken (Inventor), Tomasz Uchanski (Inventor), Andy Chevigné (Inventor), Martyna Szpakowska (Inventor)

Immuno-Pharmacology and Interactomics

Research output: Patent

Abstract

The present invention relates to the field of structural biology. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and screening. Even more specifically, the invention relates to a functional fusion protein of a cytokine and a scaffold protein wherein the scaffold is a folded protein that interrupts the topology of the cytokine to form a rigid fusion protein that retains its receptor binding and activation capacity. More specifically, chemokine- and interleukin-based functional fusion proteins, and their production and uses, are disclosed herein

Original language	English
Patent number	WO2020127983A1
IPC	C07K14/205; C07K14/52; C07K14/715; C07K19/00
Priority date	21/12/18
Publication status	Published - 25 Jun 2020

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title = "Fusion proteins comprising a cytokine and scaffold protein",

abstract = "The present invention relates to the field of structural biology. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and screening. Even more specifically, the invention relates to a functional fusion protein of a cytokine and a scaffold protein wherein the scaffold is a folded protein that interrupts the topology of the cytokine to form a rigid fusion protein that retains its receptor binding and activation capacity. More specifically, chemokine- and interleukin-based functional fusion proteins, and their production and uses, are disclosed herein",

author = "Jan Steyaert and Els Pardon and Alexandre Wohlk{\"o}nig and Valentina Kalichuk and Wim Vranken and Tomasz Uchanski and Andy Chevign{\'e} and Martyna Szpakowska",

note = "US Patent App. 17/415,355; WO2020127983A1; C07K14/205; C07K14/52; C07K14/715; C07K19/00",

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TY - PAT

T1 - Fusion proteins comprising a cytokine and scaffold protein

AU - Steyaert, Jan

AU - Pardon, Els

AU - Wohlkönig, Alexandre

AU - Kalichuk, Valentina

AU - Vranken, Wim

AU - Uchanski, Tomasz

AU - Chevigné, Andy

AU - Szpakowska, Martyna

N1 - US Patent App. 17/415,355

PY - 2020/6/25

Y1 - 2020/6/25

N2 - The present invention relates to the field of structural biology. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and screening. Even more specifically, the invention relates to a functional fusion protein of a cytokine and a scaffold protein wherein the scaffold is a folded protein that interrupts the topology of the cytokine to form a rigid fusion protein that retains its receptor binding and activation capacity. More specifically, chemokine- and interleukin-based functional fusion proteins, and their production and uses, are disclosed herein

AB - The present invention relates to the field of structural biology. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and screening. Even more specifically, the invention relates to a functional fusion protein of a cytokine and a scaffold protein wherein the scaffold is a folded protein that interrupts the topology of the cytokine to form a rigid fusion protein that retains its receptor binding and activation capacity. More specifically, chemokine- and interleukin-based functional fusion proteins, and their production and uses, are disclosed herein

UR - https://worldwide.espacenet.com/patent/search/family/065030869/publication/WO2020127983A1?q=EP18215463

UR - https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020127983

M3 - Patent

M1 - WO2020127983A1

ER -

Fusion proteins comprising a cytokine and scaffold protein

Abstract

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