Fusion proteins comprising a cytokine and scaffold protein

Jan Steyaert (Inventor), Els Pardon (Inventor), Alexandre Wohlkönig (Inventor), Valentina Kalichuk (Inventor), Wim Vranken (Inventor), Tomasz Uchanski (Inventor), Andy Chevigné (Inventor), Martyna Szpakowska (Inventor)

Research output: Patent


The present invention relates to the field of structural biology. More specifically, the present invention relates to novel fusion proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use in structure-based drug design and screening. Even more specifically, the invention relates to a functional fusion protein of a cytokine and a scaffold protein wherein the scaffold is a folded protein that interrupts the topology of the cytokine to form a rigid fusion protein that retains its receptor binding and activation capacity. More specifically, chemokine- and interleukin-based functional fusion proteins, and their production and uses, are disclosed herein
Original languageEnglish
Patent numberWO2020127983A1
IPC C07K14/205; C07K14/52; C07K14/715; C07K19/00
Priority date21/12/18
Publication statusPublished - 25 Jun 2020


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