Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease

Manu Sharma, Peter Lichtner, Rejko Kruger, Daniela Berg, Claudia Schulte, Thomas Illig, Olaf Riess, Thomas Gasser*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

A recently published whole genome association study showed the involvement of 13 SNPs in the pathogenesis of Parkinson disease (PD). We performed a replication study to assess their involvement in our sporadic cohort consisting of 663 cases and 1002 controls ascertained from Germany. One of the previously reported SNP, rs7723605, showed evidence of association (p value 0.04) in our sample. We further refined the signal by genotyping additional 22 SNPs around SNP rs7723605. Our refinement analysis, however, did not provide evidence for association in our sample after adjusting for multiple testing by permutation procedure. In conclusion, our study did not lend support to the finding that the reported SNPs are directly influencing the susceptibility to sporadic form of PD at least in our population.

Original languageEnglish
Pages (from-to)1706-1709
Number of pages4
JournalNeurobiology of Aging
Volume30
Issue number10
DOIs
Publication statusPublished - Oct 2009
Externally publishedYes

Keywords

  • Linkage disequilibrium (LD)
  • Parkinson disease
  • Whole genome association

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