Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria

Vincent Bischoff, Cécile Vignal, Ivo G. Boneca, Tatiana Michel, Jules A. Hoffmann, Julien Royet*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

199 Citations (Scopus)

Abstract

The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.

Original languageEnglish
Pages (from-to)1175-1180
Number of pages6
JournalNature Immunology
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

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