@article{1061d7670cdc4e949ac50770bd0e20c9,
title = "Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis",
abstract = "Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.",
keywords = "epidemiology, fruit, meta-analysis, review, type 2 diabetes mellitus, vegetables",
author = "Cooper, {A. J.} and Forouhi, {N. G.} and Z. Ye and B. Buijsse and L. Arriola and B. Balkau and A. Barricarte and Beulens, {J. W.J.} and H. Boeing and B{\"u}chner, {F. L.} and Dahm, {C. C.} and {De Lauzon-Guillain}, B. and G. Fagherazzi and Franks, {P. W.} and C. Gonzalez and S. Grioni and R. Kaaks and Key, {T. J.} and G. Masala and C. Navarro and P. Nilsson and K. Overvad and S. Panico and {Ram{\'o}n Quir{\'o}s}, J. and O. Rolandsson and N. Roswall and C. Sacerdote and S{\'a}nchez, {M. J.} and N. Slimani and I. Sluijs and Spijkerman, {A. M.W.} and B. Teucher and A. Tjonneland and R. Tumino and Sharp, {S. J.} and C. Langenberg and Feskens, {E. J.M.} and E. Riboli and Wareham, {N. J.}",
note = "Funding Information: We thank all EPIC participants and staff for their contribution to the study. We thank Nicola Kerrison (MRC Epidemiology Unit, Cambridge) for managing the data for the EPIC-InterAct Project. Funding for the InterAct project was provided by the EU FP6 programme (grant number LSHM_CT_2006_037197). In addition, InterAct investigators acknowledge funding from the following agencies: LA: We thank the participants of the Spanish EPIC cohort for their contribution to the study, as well as to the team of trained nurses who participated in the recruitment; JWJB: Verification of diabetes cases in EPIC-NL was additionally funded by NL Agency grant IGE05012 and an Incentive Grant from the Board of the UMC Utrecht; PWF: Swedish Research Council, Novo Nordisk, Swedish Diabetes Association, Swedish Heart-Lung Foundation; RK: German Cancer Aid; TJK: Cancer Research UK; CN: Health Research Fund (FIS) of the Spanish Ministry of Health; Murcia Regional Government (No 6236); PN: Swedish Research Council; KO: Danish Cancer Society; SP: Compagnia di San Paolo; JRQ: Asturias Regional Government; OR: The V{\"a}sterboten County Council; IS: Verification of diabetes cases was additionally funded by NL Agency grant IGE05012 and an Incentive Grant from the Board of the UMC Utrecht; AMWS: Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands; BT: German Cancer Aid; AT: Danish Cancer Society; RT: AIRE-ONLUS Ragusa, AVIS-Ragusa, Sicilian Regional Government; ER: ER was supported in this work by the Imperial College Biomedical Research Centre.",
year = "2012",
month = oct,
doi = "10.1038/ejcn.2012.85",
language = "English",
volume = "66",
pages = "1082--1092",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "Springer Nature",
number = "10",
}