TY - JOUR
T1 - From Chronodisruption to Sarcopenia
T2 - The Therapeutic Potential of Melatonin
AU - Fernández-Martínez, José
AU - Ramírez-Casas, Yolanda
AU - Yang, Yang
AU - Aranda-Martínez, Paula
AU - Martínez-Ruiz, Laura
AU - Escames, Germaine
AU - Acuña-Castroviejo, Darío
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/12
Y1 - 2023/12
N2 - Sarcopenia is an age-related condition that involves a progressive decline in muscle mass and function, leading to increased risk of falls, frailty, and mortality. Although the exact mechanisms are not fully understood, aging-related processes like inflammation, oxidative stress, reduced mitochondrial capacity, and cell apoptosis contribute to this decline. Disruption of the circadian system with age may initiate these pathways in skeletal muscle, preceding the onset of sarcopenia. At present, there is no pharmacological treatment for sarcopenia, only resistance exercise and proper nutrition may delay its onset. Melatonin, derived from tryptophan, emerges as an exceptional candidate for treating sarcopenia due to its chronobiotic, antioxidant, and anti-inflammatory properties. Its impact on mitochondria and organelle, where it is synthesized and crucial in aging skeletal muscle, further highlights its potential. In this review, we discuss the influence of clock genes in muscular aging, with special reference to peripheral clock genes in the skeletal muscle, as well as their relationship with melatonin, which is proposed as a potential therapy against sarcopenia.
AB - Sarcopenia is an age-related condition that involves a progressive decline in muscle mass and function, leading to increased risk of falls, frailty, and mortality. Although the exact mechanisms are not fully understood, aging-related processes like inflammation, oxidative stress, reduced mitochondrial capacity, and cell apoptosis contribute to this decline. Disruption of the circadian system with age may initiate these pathways in skeletal muscle, preceding the onset of sarcopenia. At present, there is no pharmacological treatment for sarcopenia, only resistance exercise and proper nutrition may delay its onset. Melatonin, derived from tryptophan, emerges as an exceptional candidate for treating sarcopenia due to its chronobiotic, antioxidant, and anti-inflammatory properties. Its impact on mitochondria and organelle, where it is synthesized and crucial in aging skeletal muscle, further highlights its potential. In this review, we discuss the influence of clock genes in muscular aging, with special reference to peripheral clock genes in the skeletal muscle, as well as their relationship with melatonin, which is proposed as a potential therapy against sarcopenia.
KW - aging
KW - Bmal1
KW - chronodisruption
KW - clock genes
KW - inflammaging
KW - melatonin
KW - mitochondria
KW - oxidative stress
KW - sarcopenia
KW - skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=85180430706&partnerID=8YFLogxK
U2 - 10.3390/biom13121779
DO - 10.3390/biom13121779
M3 - Review article
C2 - 38136651
AN - SCOPUS:85180430706
SN - 2218-273X
VL - 13
JO - Biomolecules
JF - Biomolecules
IS - 12
M1 - 1779
ER -