Folate and prevention of neural tube defects: New insights from a bayesian model

Alexander Ströhle; Torsten Bohn

doi:10.1024/0300-9831/a000229

Folate and prevention of neural tube defects: New insights from a bayesian model

Alexander Ströhle^*, Torsten Bohn

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Maternal folate status before and during pregnancy influences a woman's risk of having a pregnancy affected by congenital malformations of the neural tube (neural tube defects, NTD). For NTD prevention, it is recommended that women use periconceptional supplementation of folic acid. However, the recommended dose varies considerably (400 - 800 μg folic acid/day). Insufficient data exists on the relation between folate status and the risk of NTD. A recent study published in the British Medical Journal provides evidence for a generalizable dose-response relation between folate status and risk of NTD. The lowest risk of having a child with NTD was related to red blood cell (RBC) folate concentrations of ≥ 1000 nmol/L.

Original language	English
Pages (from-to)	109-111
Number of pages	3
Journal	International Journal for Vitamin and Nutrition Research
Volume	85
Issue number	3-4
DOIs	https://doi.org/10.1024/0300-9831/a000229
Publication status	Published - 2015
Externally published	Yes

Access to Document

10.1024/0300-9831/a000229

Cite this

@article{3e648a0d0ef14c38b36dfe7c31ff9eca,

title = "Folate and prevention of neural tube defects: New insights from a bayesian model",

abstract = "Maternal folate status before and during pregnancy influences a woman's risk of having a pregnancy affected by congenital malformations of the neural tube (neural tube defects, NTD). For NTD prevention, it is recommended that women use periconceptional supplementation of folic acid. However, the recommended dose varies considerably (400 - 800 μg folic acid/day). Insufficient data exists on the relation between folate status and the risk of NTD. A recent study published in the British Medical Journal provides evidence for a generalizable dose-response relation between folate status and risk of NTD. The lowest risk of having a child with NTD was related to red blood cell (RBC) folate concentrations of ≥ 1000 nmol/L.",

author = "Alexander Str{\"o}hle and Torsten Bohn",

note = "Publisher Copyright: {\textcopyright} 2015 Hans Huber Publishers, Hogrefe AG, Bern.",

year = "2015",

doi = "10.1024/0300-9831/a000229",

language = "English",

volume = "85",

pages = "109--111",

journal = "International Journal for Vitamin and Nutrition Research",

issn = "0300-9831",

publisher = "IMR Press Limited",

number = "3-4",

}

TY - JOUR

T1 - Folate and prevention of neural tube defects

T2 - New insights from a bayesian model

AU - Ströhle, Alexander

AU - Bohn, Torsten

PY - 2015

Y1 - 2015

N2 - Maternal folate status before and during pregnancy influences a woman's risk of having a pregnancy affected by congenital malformations of the neural tube (neural tube defects, NTD). For NTD prevention, it is recommended that women use periconceptional supplementation of folic acid. However, the recommended dose varies considerably (400 - 800 μg folic acid/day). Insufficient data exists on the relation between folate status and the risk of NTD. A recent study published in the British Medical Journal provides evidence for a generalizable dose-response relation between folate status and risk of NTD. The lowest risk of having a child with NTD was related to red blood cell (RBC) folate concentrations of ≥ 1000 nmol/L.

AB - Maternal folate status before and during pregnancy influences a woman's risk of having a pregnancy affected by congenital malformations of the neural tube (neural tube defects, NTD). For NTD prevention, it is recommended that women use periconceptional supplementation of folic acid. However, the recommended dose varies considerably (400 - 800 μg folic acid/day). Insufficient data exists on the relation between folate status and the risk of NTD. A recent study published in the British Medical Journal provides evidence for a generalizable dose-response relation between folate status and risk of NTD. The lowest risk of having a child with NTD was related to red blood cell (RBC) folate concentrations of ≥ 1000 nmol/L.

UR - http://www.scopus.com/inward/record.url?scp=84962182329&partnerID=8YFLogxK

U2 - 10.1024/0300-9831/a000229

DO - 10.1024/0300-9831/a000229

M3 - Article

C2 - 26780389

AN - SCOPUS:84962182329

SN - 0300-9831

VL - 85

SP - 109

EP - 111

JO - International Journal for Vitamin and Nutrition Research

JF - International Journal for Vitamin and Nutrition Research

IS - 3-4

ER -

Folate and prevention of neural tube defects: New insights from a bayesian model

Abstract

Access to Document

Other files and links

Fingerprint

Cite this