FIMICS: A panel of long noncoding RNAs for cardiovascular conditions

Huseyin Firat; Lu Zhang; Shounak Baksi; Przemyslaw Leszek; Eric Schordan; Samir Ounzain; Jan Kottwitz; Dimitri Patriki; Bettina Heidecker; Thomas F. Lüscher; Thierry Pedrazzini; Yvan Devaux; the EU-CardioRNA COST Action (CA17129)

doi:10.1016/j.heliyon.2023.e13087

FIMICS: A panel of long noncoding RNAs for cardiovascular conditions

Huseyin Firat
, Lu Zhang
, Shounak Baksi
, Przemyslaw Leszek
, Eric Schordan
, Samir Ounzain
, Jan Kottwitz
, Dimitri Patriki
, Bettina Heidecker
, Thomas F. Lüscher
, Thierry Pedrazzini
, Yvan Devaux^*
, the EU-CardioRNA COST Action (CA17129)

^*Corresponding author for this work

Cardiovascular Research Unit

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratification via identification of novel biomarkers could improve management of cardiovascular diseases of complex etiologies. Long-noncoding RNAs (lncRNAs) are highly tissue-specific in nature and have emerged as important biomarkers in human diseases. In this study, we aimed to identify cardiac-enriched lncRNAs as potential biomarkers for cardiovascular conditions. Deep RNA sequencing and quantitative PCR identified differentially expressed lncRNAs between failing and non-failing hearts. An independent dataset was used to evaluate the enrichment of lncRNAs in normal hearts. We identified a panel of 2906 lncRNAs, named FIMICS, that were either cardiac-enriched or differentially expressed between failing and non-failing hearts. Expression of lncRNAs in blood samples differentiated patients with myocarditis and acute myocardial infarction. We hereby present the FIMICS panel, a readily available tool to provide insights into cardiovascular pathologies and which could be helpful for diagnosis, monitoring and prognosis purposes.

Original language	English
Article number	e13087
Journal	Heliyon
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/j.heliyon.2023.e13087
Publication status	Published - Jan 2023

Keywords

Biomarker
Cardiac enriched RNA
Cardiovascular condition
Deep RNA sequencing
Heart failure
Long-noncoding RNA

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@article{5e340c42fd8144378edb73af8fed552b,

title = "FIMICS: A panel of long noncoding RNAs for cardiovascular conditions",

abstract = "Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratification via identification of novel biomarkers could improve management of cardiovascular diseases of complex etiologies. Long-noncoding RNAs (lncRNAs) are highly tissue-specific in nature and have emerged as important biomarkers in human diseases. In this study, we aimed to identify cardiac-enriched lncRNAs as potential biomarkers for cardiovascular conditions. Deep RNA sequencing and quantitative PCR identified differentially expressed lncRNAs between failing and non-failing hearts. An independent dataset was used to evaluate the enrichment of lncRNAs in normal hearts. We identified a panel of 2906 lncRNAs, named FIMICS, that were either cardiac-enriched or differentially expressed between failing and non-failing hearts. Expression of lncRNAs in blood samples differentiated patients with myocarditis and acute myocardial infarction. We hereby present the FIMICS panel, a readily available tool to provide insights into cardiovascular pathologies and which could be helpful for diagnosis, monitoring and prognosis purposes.",

keywords = "Biomarker, Cardiac enriched RNA, Cardiovascular condition, Deep RNA sequencing, Heart failure, Long-noncoding RNA",

author = "Huseyin Firat and Lu Zhang and Shounak Baksi and Przemyslaw Leszek and Eric Schordan and Samir Ounzain and Jan Kottwitz and Dimitri Patriki and Bettina Heidecker and L{\"u}scher, \{Thomas F.\} and Thierry Pedrazzini and Yvan Devaux and \{the EU-CardioRNA COST Action (CA17129)\}",

note = "Funding Information: This publication is based upon work from the EU-CardioRNA COST ACTION CA17129, supported by COST (European Cooperation in Science and Technology). Funding Information: This work is supported by funding from the EU Horizon 2020 project COVIRNA (Grant Agreement \# 101016072 ), the National Research Fund (grants \# C14/BM/8225223 , C17/BM/11613033 and COVID-19/2020-1/14719577/miRCOVID ), the Ministry of Higher Education and Research, and the Heart Foundation-Daniel Wagner of Luxembourg to Y.D. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = jan,

doi = "10.1016/j.heliyon.2023.e13087",

language = "English",

volume = "9",

journal = "Heliyon",

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T1 - FIMICS

T2 - A panel of long noncoding RNAs for cardiovascular conditions

AU - Firat, Huseyin

AU - Zhang, Lu

AU - Baksi, Shounak

AU - Leszek, Przemyslaw

AU - Schordan, Eric

AU - Ounzain, Samir

AU - Kottwitz, Jan

AU - Patriki, Dimitri

AU - Heidecker, Bettina

AU - Lüscher, Thomas F.

AU - Pedrazzini, Thierry

AU - Devaux, Yvan

AU - the EU-CardioRNA COST Action (CA17129)

N1 - Funding Information: This publication is based upon work from the EU-CardioRNA COST ACTION CA17129, supported by COST (European Cooperation in Science and Technology). Funding Information: This work is supported by funding from the EU Horizon 2020 project COVIRNA (Grant Agreement # 101016072 ), the National Research Fund (grants # C14/BM/8225223 , C17/BM/11613033 and COVID-19/2020-1/14719577/miRCOVID ), the Ministry of Higher Education and Research, and the Heart Foundation-Daniel Wagner of Luxembourg to Y.D. Publisher Copyright: © 2023 The Authors

PY - 2023/1

Y1 - 2023/1

N2 - Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratification via identification of novel biomarkers could improve management of cardiovascular diseases of complex etiologies. Long-noncoding RNAs (lncRNAs) are highly tissue-specific in nature and have emerged as important biomarkers in human diseases. In this study, we aimed to identify cardiac-enriched lncRNAs as potential biomarkers for cardiovascular conditions. Deep RNA sequencing and quantitative PCR identified differentially expressed lncRNAs between failing and non-failing hearts. An independent dataset was used to evaluate the enrichment of lncRNAs in normal hearts. We identified a panel of 2906 lncRNAs, named FIMICS, that were either cardiac-enriched or differentially expressed between failing and non-failing hearts. Expression of lncRNAs in blood samples differentiated patients with myocarditis and acute myocardial infarction. We hereby present the FIMICS panel, a readily available tool to provide insights into cardiovascular pathologies and which could be helpful for diagnosis, monitoring and prognosis purposes.

AB - Cardiovascular disorders such as heart failure are leading causes of mortality. Patient stratification via identification of novel biomarkers could improve management of cardiovascular diseases of complex etiologies. Long-noncoding RNAs (lncRNAs) are highly tissue-specific in nature and have emerged as important biomarkers in human diseases. In this study, we aimed to identify cardiac-enriched lncRNAs as potential biomarkers for cardiovascular conditions. Deep RNA sequencing and quantitative PCR identified differentially expressed lncRNAs between failing and non-failing hearts. An independent dataset was used to evaluate the enrichment of lncRNAs in normal hearts. We identified a panel of 2906 lncRNAs, named FIMICS, that were either cardiac-enriched or differentially expressed between failing and non-failing hearts. Expression of lncRNAs in blood samples differentiated patients with myocarditis and acute myocardial infarction. We hereby present the FIMICS panel, a readily available tool to provide insights into cardiovascular pathologies and which could be helpful for diagnosis, monitoring and prognosis purposes.

KW - Biomarker

KW - Cardiac enriched RNA

KW - Cardiovascular condition

KW - Deep RNA sequencing

KW - Heart failure

KW - Long-noncoding RNA

UR - https://www.scopus.com/pages/publications/85146882039

UR - https://pubmed.ncbi.nlm.nih.gov/36747920

U2 - 10.1016/j.heliyon.2023.e13087

DO - 10.1016/j.heliyon.2023.e13087

M3 - Article

C2 - 36747920

AN - SCOPUS:85146882039

SN - 2405-8440

VL - 9

JO - Heliyon

JF - Heliyon

IS - 1

M1 - e13087

ER -

FIMICS: A panel of long noncoding RNAs for cardiovascular conditions

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Keywords

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