Expression of measles virus antigens in Streptococcus gordonii

T. Maggi*, M. R. Oggioni, D. Medaglini, M. L. Bianchi Bandinelli, D. Soldateschi, K. H. Wiesmüller, C. P. Muller, P. E. Valensin, G. Pozzi

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalNew Microbiologica
Issue number2
Publication statusPublished - Apr 2000
Externally publishedYes


  • Measles virus antigens
  • Measles virus vaccines
  • Recombinant vaccines
  • Streptococcus gordonii
  • Vaccine vectors


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