Expression of measles virus antigens in Streptococcus gordonii

T. Maggi; M. R. Oggioni; D. Medaglini; M. L. Bianchi Bandinelli; D. Soldateschi; K. H. Wiesmüller; C. P. Muller; P. E. Valensin; G. Pozzi

Expression of measles virus antigens in Streptococcus gordonii

T. Maggi^*, M. R. Oggioni, D. Medaglini, M. L. Bianchi Bandinelli, D. Soldateschi, K. H. Wiesmüller, C. P. Muller, P. E. Valensin, G. Pozzi

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.

Original language	English
Pages (from-to)	119-128
Number of pages	10
Journal	New Microbiologica
Volume	23
Issue number	2
Publication status	Published - Apr 2000
Externally published	Yes

Keywords

Measles virus antigens
Measles virus vaccines
Recombinant vaccines
Streptococcus gordonii
Vaccine vectors

Cite this

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title = "Expression of measles virus antigens in Streptococcus gordonii",

abstract = "The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.",

keywords = "Measles virus antigens, Measles virus vaccines, Recombinant vaccines, Streptococcus gordonii, Vaccine vectors",

author = "T. Maggi and Oggioni, {M. R.} and D. Medaglini and {Bianchi Bandinelli}, {M. L.} and D. Soldateschi and Wiesm{\"u}ller, {K. H.} and Muller, {C. P.} and Valensin, {P. E.} and G. Pozzi",

year = "2000",

month = apr,

language = "English",

volume = "23",

pages = "119--128",

journal = "New Microbiologica",

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T1 - Expression of measles virus antigens in Streptococcus gordonii

AU - Maggi, T.

AU - Oggioni, M. R.

AU - Medaglini, D.

AU - Bianchi Bandinelli, M. L.

AU - Soldateschi, D.

AU - Wiesmüller, K. H.

AU - Muller, C. P.

AU - Valensin, P. E.

AU - Pozzi, G.

PY - 2000/4

Y1 - 2000/4

N2 - The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.

AB - The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.

KW - Measles virus antigens

KW - Measles virus vaccines

KW - Recombinant vaccines

KW - Streptococcus gordonii

KW - Vaccine vectors

UR - http://www.scopus.com/inward/record.url?scp=0034168257&partnerID=8YFLogxK

M3 - Article

C2 - 10872681

AN - SCOPUS:0034168257

SN - 1121-7138

VL - 23

SP - 119

EP - 128

JO - New Microbiologica

JF - New Microbiologica

IS - 2

ER -

Expression of measles virus antigens in Streptococcus gordonii

Abstract

Keywords

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