TY - JOUR
T1 - Expression of interleukin-16 by microglial cells in inflammatory, autoimmune, and degenerative lesions of the rat brain
AU - Guo, Liang Hao
AU - Mittelbronn, Michel
AU - Brabeck, Christine
AU - Mueller, Christian A.
AU - Schluesener, Hermann J.
N1 - Funding Information:
This work has been supported by a grant from the Hertie Foundation.
PY - 2004/1
Y1 - 2004/1
N2 - Here we report a comparative analysis of interleukin-16 (IL-16) expression by microglial cells of the normal rat brain in trimethyltin (TMT) neurotoxicity, experimental autoimmune uveitis (EAU), encephalomyelitis (EAE), and viral infection (Borna disease, Borna disease virus) by immunohistochemistry. Striking differences were observed. In contrast to the human brain, IL-16 was not expressed constitutively in the rat brain. Remote activation of microglial cells of the optic tract in EAU did not result into IL-16 expression. TMT intoxication induced expression in microglial cells of the hippocampus. In EAE and BDV, massive IL-16+ microglial cells could be seen. Thus, IL-16 is a descriptor of microglial cell activation that discriminates between different disease models, and might be a valuable marker for the detection of microglia activation in human and rat central nervous system (CNS) diseases.
AB - Here we report a comparative analysis of interleukin-16 (IL-16) expression by microglial cells of the normal rat brain in trimethyltin (TMT) neurotoxicity, experimental autoimmune uveitis (EAU), encephalomyelitis (EAE), and viral infection (Borna disease, Borna disease virus) by immunohistochemistry. Striking differences were observed. In contrast to the human brain, IL-16 was not expressed constitutively in the rat brain. Remote activation of microglial cells of the optic tract in EAU did not result into IL-16 expression. TMT intoxication induced expression in microglial cells of the hippocampus. In EAE and BDV, massive IL-16+ microglial cells could be seen. Thus, IL-16 is a descriptor of microglial cell activation that discriminates between different disease models, and might be a valuable marker for the detection of microglia activation in human and rat central nervous system (CNS) diseases.
KW - Autoimmunity
KW - CNS
KW - Inflammation
KW - Interleukin-16
KW - Microglia
KW - Neurodegeneration
UR - http://www.scopus.com/inward/record.url?scp=0347362897&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2003.09.017
DO - 10.1016/j.jneuroim.2003.09.017
M3 - Article
C2 - 14698845
AN - SCOPUS:0347362897
SN - 0165-5728
VL - 146
SP - 39
EP - 45
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -