TY - JOUR
T1 - Exploring the application of dietary antioxidant index for disease risk assessment
T2 - a comprehensive review
AU - Pourmontaseri, Hossein
AU - Bazmi, Sina
AU - Sepehrinia, Matin
AU - Mostafavi, Ayda
AU - Arefnezhad, Reza
AU - Homayounfar, Reza
AU - Vahid, Farhad
N1 - Funding:
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Publisher Copyright:
Copyright © 2025 Pourmontaseri, Bazmi, Sepehrinia, Mostafavi, Arefnezhad, Homayounfar and Vahid.
PY - 2025/1/16
Y1 - 2025/1/16
N2 - Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others. Dietary antioxidants can be obtained from various sources, mainly through a plant-based diet, including fruits and vegetables. The dietary antioxidant index (DAI) has been developed to assess total antioxidant intake from diet. This review delineated the performance of DAI in the risk assessment of different diseases. It is suggested that a high DAI score prevents obesity-related diseases, including diabetes mellitus, hyperuricemia, dyslipidemia, and metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, DAI is negatively associated with Helicobacter pylori and Human papillomavirus infection, thus reducing the risk of gastric and cervical cancer. Also, a high intake of antioxidants prevents the development of osteoporosis, miscarriage, infertility, and mental illnesses. However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied.
AB - Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others. Dietary antioxidants can be obtained from various sources, mainly through a plant-based diet, including fruits and vegetables. The dietary antioxidant index (DAI) has been developed to assess total antioxidant intake from diet. This review delineated the performance of DAI in the risk assessment of different diseases. It is suggested that a high DAI score prevents obesity-related diseases, including diabetes mellitus, hyperuricemia, dyslipidemia, and metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, DAI is negatively associated with Helicobacter pylori and Human papillomavirus infection, thus reducing the risk of gastric and cervical cancer. Also, a high intake of antioxidants prevents the development of osteoporosis, miscarriage, infertility, and mental illnesses. However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied.
KW - cancer
KW - cardiovascular diseases
KW - infertility
KW - mental disorders
KW - metabolic disease
KW - obesity
KW - osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=85216479333&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/39885868/
U2 - 10.3389/fnut.2024.1497364
DO - 10.3389/fnut.2024.1497364
M3 - Review article
C2 - 39885868
AN - SCOPUS:85216479333
SN - 2296-861X
VL - 11
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
M1 - 1497364
ER -