Experimental vaccines against measles in a world of changing epidemiology

Mike M. Pütz, Fabienne B. Bouche, Rik L. De Swart, Claude P. Muller*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

33 Citations (Scopus)

Abstract

Vaccination with the current live attenuated measles vaccine is one of the most successful and cost-effective medical interventions. However, as a result of persisting maternal antibodies and immaturity of the infant immune system, this vaccine is poorly immunogenic in children <9 months old. Immunity against the live vaccine is less robust than natural immunity and protection less durable. There may also be some concern about (vaccine) virus spread during the final stage of an eventual measles eradication program. Opinions may differ with respect to the potential threat that some of these concerns may be to the World Health Organisation goal of measles elimination, but there is a consensus that the development of new measles vaccines cannot wait. Candidate vaccines are based on viral or bacterial vectors expressing recombinant viral proteins, naked DNA, immune stimulating complexes or synthetic peptides mimicking neutralising epitopes. While some of these candidate vaccines have proven their efficacy in monkey studies, aerosol formulated live attenuated measles vaccine are evaluated in clinical trials.

Original languageEnglish
Pages (from-to)525-545
Number of pages21
JournalInternational Journal for Parasitology
Volume33
Issue number5-6
DOIs
Publication statusPublished - May 2003
Externally publishedYes

Keywords

  • Bacterial vector
  • Epidemiology
  • Live attenuated vaccine
  • Measles virus
  • Recombinant protein
  • Synthetic peptide
  • Viral vector

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