Exceptional genetic variability of hepatitis B virus indicates that Rwanda is east of an emerging African genotype E/A1 divide

Judith M. Hübschen, Jules Mugabo, Cécile Alexandra Peltier, Jean Claude Karasi, Aurélie Sausy, Pierre Kirpach, Vic Arendt, Claude P. Muller

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Abstract

In Western Africa, hepatitis B virus (HBV) genotype E predominates throughout a vast crescent spanning from Senegal to Namibia and at least to the Central African Republic to the East. Although from most of the eastern parts of sub-Saharan Africa only limited sets of strains have been characterized, these belong predominantly to genotype A. To study how far the genotype E crescent extends to the East, a larger number of HBV strains from Rwanda were analyzed. Phylogenetic analysis of 45 S fragment sequences revealed strains of genotypes A (n = 30), D (n = 10), C (n = 4), and B (n = 1). Twelve genotype A sequences formed a new cluster clearly separated from the reference strains of theknown sub-genotypes. Thus, with four genotypes and at least six sub-genotypes and a new cluster of genotype A strains, HBV shows an exceptional genetic variability in this small country, unprecedented in sub-Saharan Africa. Despite this exceptional genetic variability, not a single genotype E virus was found indicating that this country does not belong to the genotype E crescent, but is east of an emerging African genotype E/A1 divide.

Original languageEnglish
Pages (from-to)435-440
Number of pages6
JournalJournal of Medical Virology
Volume81
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Genotyping
  • Molecular epidemiology
  • Phylogeny

Fingerprint

Dive into the research topics of 'Exceptional genetic variability of hepatitis B virus indicates that Rwanda is east of an emerging African genotype E/A1 divide'. Together they form a unique fingerprint.

Cite this