Evidence that oxidative stress is linked to anxiety-related behaviour in mice

Hassan Rammal, Jaouad Bouayed*, Chafique Younos, Rachid Soulimani

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

164 Citations (Scopus)


Oxidative stress in central and peripheral systems is involved in many diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and several psychiatric disorders. In the present study, the brain and peripheral oxidative status of non-anxious and anxious mice was evaluated using 2′,7′-dichlorofluorescin diacetate (DCFH-DA), a sensor of reactive oxygen species (ROS). Here we report that anxiety levels are linked to the oxidative status in both neuronal and glial cells in the cerebellum and hippocampus, in neurons of the cerebral cortex and in peripheral leucocytes (monocytes, granulocytes and lymphocytes), revealing the presence of oxidative stress in the central and peripheral systems of anxious mice. These findings suggest the redox system in anxious mice may play a role in neuroinflammation and neurodegeneration, predisposing them to recurrent infections and chronic inflammation.

Original languageEnglish
Pages (from-to)1156-1159
Number of pages4
JournalBrain, Behavior, and Immunity
Issue number8
Publication statusPublished - Nov 2008
Externally publishedYes


  • Anxiety
  • Anxious mice
  • Non-anxious mice
  • Oxidative status
  • Oxidative stress
  • ROS


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