Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Kan Xie; Frauke Neff; Astrid Markert; Jan Rozman; Juan Antonio Aguilar-Pimentel; Oana Veronica Amarie; Lore Becker; Robert Brommage; Lillian Garrett; Kristin S. Henzel; Sabine M. Hölter; Dirk Janik; Isabelle Lehmann; Kristin Moreth; Brandon L. Pearson; Ildiko Racz; Birgit Rathkolb; Devon P. Ryan; Susanne Schröder; Irina Treise; Raffi Bekeredjian; Dirk H. Busch; Jochen Graw; Gerhard Ehninger; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Michael Sandholzer; Carsten Schmidt-Weber; Marco Weiergräber; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Valerie Gailus-Durner; Helmut Fuchs; Martin Hrabě De Angelis; Dan Ehninger

doi:10.1038/s41467-017-00178-3

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Kan Xie
, Frauke Neff
, Astrid Markert
, Jan Rozman
, Juan Antonio Aguilar-Pimentel
, Oana Veronica Amarie
, Lore Becker
, Robert Brommage
, Lillian Garrett
, Kristin S. Henzel
, Sabine M. Hölter
, Dirk Janik
, Isabelle Lehmann
, Kristin Moreth
, Brandon L. Pearson
, Ildiko Racz
, Birgit Rathkolb
, Devon P. Ryan
, Susanne Schröder
, Irina Treise

Raffi Bekeredjian, Dirk H. Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě De Angelis, Dan Ehninger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

105 Citations (Scopus)

Abstract

Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

Original language	English
Article number	155
Journal	Nature Communications
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41467-017-00178-3
Publication status	Published - 1 Dec 2017

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Xie, K., Neff, F., Markert, A., Rozman, J., Aguilar-Pimentel, J. A., Amarie, O. V., Becker, L., Brommage, R., Garrett, L., Henzel, K. S., Hölter, S. M., Janik, D., Lehmann, I., Moreth, K., Pearson, B. L., Racz, I., Rathkolb, B., Ryan, D. P., Schröder, S., ... Ehninger, D. (2017). Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nature Communications, 8(1), Article 155. https://doi.org/10.1038/s41467-017-00178-3

@article{810f0bd5c5114e21bcadb9b04330aa7d,

title = "Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice",

abstract = "Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.",

author = "Kan Xie and Frauke Neff and Astrid Markert and Jan Rozman and Aguilar-Pimentel, \{Juan Antonio\} and Amarie, \{Oana Veronica\} and Lore Becker and Robert Brommage and Lillian Garrett and Henzel, \{Kristin S.\} and H{\"o}lter, \{Sabine M.\} and Dirk Janik and Isabelle Lehmann and Kristin Moreth and Pearson, \{Brandon L.\} and Ildiko Racz and Birgit Rathkolb and Ryan, \{Devon P.\} and Susanne Schr{\"o}der and Irina Treise and Raffi Bekeredjian and Busch, \{Dirk H.\} and Jochen Graw and Gerhard Ehninger and Martin Klingenspor and Thomas Klopstock and Markus Ollert and Michael Sandholzer and Carsten Schmidt-Weber and Marco Weiergr{\"a}ber and Eckhard Wolf and Wolfgang Wurst and Andreas Zimmer and Valerie Gailus-Durner and Helmut Fuchs and \{Hrab{\v e} De Angelis\}, Martin and Dan Ehninger",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = dec,

day = "1",

doi = "10.1038/s41467-017-00178-3",

language = "English",

volume = "8",

journal = "Nature Communications",

issn = "2041-1723",

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Xie, K, Neff, F, Markert, A, Rozman, J, Aguilar-Pimentel, JA, Amarie, OV, Becker, L, Brommage, R, Garrett, L, Henzel, KS, Hölter, SM, Janik, D, Lehmann, I, Moreth, K, Pearson, BL, Racz, I, Rathkolb, B, Ryan, DP, Schröder, S, Treise, I, Bekeredjian, R, Busch, DH, Graw, J, Ehninger, G, Klingenspor, M, Klopstock, T, Ollert, M, Sandholzer, M, Schmidt-Weber, C, Weiergräber, M, Wolf, E, Wurst, W, Zimmer, A, Gailus-Durner, V, Fuchs, H, Hrabě De Angelis, M & Ehninger, D 2017, 'Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice', Nature Communications, vol. 8, no. 1, 155. https://doi.org/10.1038/s41467-017-00178-3

TY - JOUR

T1 - Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

AU - Xie, Kan

AU - Neff, Frauke

AU - Markert, Astrid

AU - Rozman, Jan

AU - Aguilar-Pimentel, Juan Antonio

AU - Amarie, Oana Veronica

AU - Becker, Lore

AU - Brommage, Robert

AU - Garrett, Lillian

AU - Henzel, Kristin S.

AU - Hölter, Sabine M.

AU - Janik, Dirk

AU - Lehmann, Isabelle

AU - Moreth, Kristin

AU - Pearson, Brandon L.

AU - Racz, Ildiko

AU - Rathkolb, Birgit

AU - Ryan, Devon P.

AU - Schröder, Susanne

AU - Treise, Irina

AU - Bekeredjian, Raffi

AU - Busch, Dirk H.

AU - Graw, Jochen

AU - Ehninger, Gerhard

AU - Klingenspor, Martin

AU - Klopstock, Thomas

AU - Ollert, Markus

AU - Sandholzer, Michael

AU - Schmidt-Weber, Carsten

AU - Weiergräber, Marco

AU - Wolf, Eckhard

AU - Wurst, Wolfgang

AU - Zimmer, Andreas

AU - Gailus-Durner, Valerie

AU - Fuchs, Helmut

AU - Hrabě De Angelis, Martin

AU - Ehninger, Dan

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

AB - Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

UR - https://www.scopus.com/pages/publications/85026551882

UR - https://pubmed.ncbi.nlm.nih.gov/28761067

U2 - 10.1038/s41467-017-00178-3

DO - 10.1038/s41467-017-00178-3

M3 - Article

C2 - 28761067

AN - SCOPUS:85026551882

SN - 2041-1723

VL - 8

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 155

ER -

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

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