Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Kan Xie; Frauke Neff; Astrid Markert; Jan Rozman; Juan Antonio Aguilar-Pimentel; Oana Veronica Amarie; Lore Becker; Robert Brommage; Lillian Garrett; Kristin S. Henzel; Sabine M. Hölter; Dirk Janik; Isabelle Lehmann; Kristin Moreth; Brandon L. Pearson; Ildiko Racz; Birgit Rathkolb; Devon P. Ryan; Susanne Schröder; Irina Treise; Raffi Bekeredjian; Dirk H. Busch; Jochen Graw; Gerhard Ehninger; Martin Klingenspor; Thomas Klopstock; Markus Ollert; Michael Sandholzer; Carsten Schmidt-Weber; Marco Weiergräber; Eckhard Wolf; Wolfgang Wurst; Andreas Zimmer; Valerie Gailus-Durner; Helmut Fuchs; Martin Hrabě De Angelis; Dan Ehninger

doi:10.1038/s41467-017-00178-3

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Kan Xie, Frauke Neff, Astrid Markert, Jan Rozman, Juan Antonio Aguilar-Pimentel, Oana Veronica Amarie, Lore Becker, Robert Brommage, Lillian Garrett, Kristin S. Henzel, Sabine M. Hölter, Dirk Janik, Isabelle Lehmann, Kristin Moreth, Brandon L. Pearson, Ildiko Racz, Birgit Rathkolb, Devon P. Ryan, Susanne Schröder, Irina TreiseRaffi Bekeredjian, Dirk H. Busch, Jochen Graw, Gerhard Ehninger, Martin Klingenspor, Thomas Klopstock, Markus Ollert, Michael Sandholzer, Carsten Schmidt-Weber, Marco Weiergräber, Eckhard Wolf, Wolfgang Wurst, Andreas Zimmer, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabě De Angelis, Dan Ehninger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

84 Citations (Scopus)

Abstract

Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

Original language	English
Article number	155
Journal	Nature Communications
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41467-017-00178-3
Publication status	Published - 1 Dec 2017

Access to Document

10.1038/s41467-017-00178-3

Cite this

Xie, K., Neff, F., Markert, A., Rozman, J., Aguilar-Pimentel, J. A., Amarie, O. V., Becker, L., Brommage, R., Garrett, L., Henzel, K. S., Hölter, S. M., Janik, D., Lehmann, I., Moreth, K., Pearson, B. L., Racz, I., Rathkolb, B., Ryan, D. P., Schröder, S., ... Ehninger, D. (2017). Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice. Nature Communications, 8(1), Article 155. https://doi.org/10.1038/s41467-017-00178-3

@article{810f0bd5c5114e21bcadb9b04330aa7d,

title = "Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice",

abstract = "Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.",

author = "Kan Xie and Frauke Neff and Astrid Markert and Jan Rozman and Aguilar-Pimentel, {Juan Antonio} and Amarie, {Oana Veronica} and Lore Becker and Robert Brommage and Lillian Garrett and Henzel, {Kristin S.} and H{\"o}lter, {Sabine M.} and Dirk Janik and Isabelle Lehmann and Kristin Moreth and Pearson, {Brandon L.} and Ildiko Racz and Birgit Rathkolb and Ryan, {Devon P.} and Susanne Schr{\"o}der and Irina Treise and Raffi Bekeredjian and Busch, {Dirk H.} and Jochen Graw and Gerhard Ehninger and Martin Klingenspor and Thomas Klopstock and Markus Ollert and Michael Sandholzer and Carsten Schmidt-Weber and Marco Weiergr{\"a}ber and Eckhard Wolf and Wolfgang Wurst and Andreas Zimmer and Valerie Gailus-Durner and Helmut Fuchs and {Hrab{\v e} De Angelis}, Martin and Dan Ehninger",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = dec,

day = "1",

doi = "10.1038/s41467-017-00178-3",

language = "English",

volume = "8",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

number = "1",

}

Xie, K, Neff, F, Markert, A, Rozman, J, Aguilar-Pimentel, JA, Amarie, OV, Becker, L, Brommage, R, Garrett, L, Henzel, KS, Hölter, SM, Janik, D, Lehmann, I, Moreth, K, Pearson, BL, Racz, I, Rathkolb, B, Ryan, DP, Schröder, S, Treise, I, Bekeredjian, R, Busch, DH, Graw, J, Ehninger, G, Klingenspor, M, Klopstock, T, Ollert, M, Sandholzer, M, Schmidt-Weber, C, Weiergräber, M, Wolf, E, Wurst, W, Zimmer, A, Gailus-Durner, V, Fuchs, H, Hrabě De Angelis, M & Ehninger, D 2017, 'Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice', Nature Communications, vol. 8, no. 1, 155. https://doi.org/10.1038/s41467-017-00178-3

TY - JOUR

T1 - Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

AU - Xie, Kan

AU - Neff, Frauke

AU - Markert, Astrid

AU - Rozman, Jan

AU - Aguilar-Pimentel, Juan Antonio

AU - Amarie, Oana Veronica

AU - Becker, Lore

AU - Brommage, Robert

AU - Garrett, Lillian

AU - Henzel, Kristin S.

AU - Hölter, Sabine M.

AU - Janik, Dirk

AU - Lehmann, Isabelle

AU - Moreth, Kristin

AU - Pearson, Brandon L.

AU - Racz, Ildiko

AU - Rathkolb, Birgit

AU - Ryan, Devon P.

AU - Schröder, Susanne

AU - Treise, Irina

AU - Bekeredjian, Raffi

AU - Busch, Dirk H.

AU - Graw, Jochen

AU - Ehninger, Gerhard

AU - Klingenspor, Martin

AU - Klopstock, Thomas

AU - Ollert, Markus

AU - Sandholzer, Michael

AU - Schmidt-Weber, Carsten

AU - Weiergräber, Marco

AU - Wolf, Eckhard

AU - Wurst, Wolfgang

AU - Zimmer, Andreas

AU - Gailus-Durner, Valerie

AU - Fuchs, Helmut

AU - Hrabě De Angelis, Martin

AU - Ehninger, Dan

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

AB - Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.

UR - http://www.scopus.com/inward/record.url?scp=85026551882&partnerID=8YFLogxK

UR - https://pubmed.ncbi.nlm.nih.gov/28761067

U2 - 10.1038/s41467-017-00178-3

DO - 10.1038/s41467-017-00178-3

M3 - Article

C2 - 28761067

AN - SCOPUS:85026551882

SN - 2041-1723

VL - 8

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 155

ER -

Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice

Abstract

Access to Document

Other files and links

Fingerprint

Cite this