Evaluation of the γ-synuclein gene in German Parkinson's disease patients

Rejko Krüger; Ludger Schöls; Thomas Müller; Wilfried Kuhn; Dirk Woitalla; Horst Przuntek; Jörg T. Epplen; Olaf Riess

doi:10.1016/S0304-3940(01)02127-9

Evaluation of the γ-synuclein gene in German Parkinson's disease patients

Rejko Krüger^*, Ludger Schöls, Thomas Müller, Wilfried Kuhn, Dirk Woitalla, Horst Przuntek, Jörg T. Epplen, Olaf Riess

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Abstract

Mutations in the α-synuclein gene are responsible for an autosomal-dominantly inherited form of Parkinson's disease (PD) and α-synuclein was found to be the major component of Lewy bodies in PD. Because of the high homology to α-synuclein and the abundance in neuronal tissues, we investigated the γ-synuclein gene in PD. We analyzed 262 German PD patients and 179 healthy German controls via two polymorphisms in the γ-synuclein gene. No significant differences in the allelic or genotypic distributions of the investigated polymorphisms were observed between patients and controls. In addition no evidence for an increased risk of combined genotypes of polymorphisms in the γ-synuclein and the α-synuclein gene was found. Therefore, our results do not support a major role of the γ-synuclein gene in PD.

Original language	English
Pages (from-to)	191-193
Number of pages	3
Journal	Neuroscience Letters
Volume	310
Issue number	2-3
DOIs	https://doi.org/10.1016/S0304-3940(01)02127-9
Publication status	Published - 14 Sept 2001
Externally published	Yes

Keywords

Genetics
Lewy body
Neurodegeneration
Parkinson's disease
Protein aggregation
α-synuclein
γ-synuclein

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10.1016/S0304-3940(01)02127-9

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title = "Evaluation of the γ-synuclein gene in German Parkinson's disease patients",

abstract = "Mutations in the α-synuclein gene are responsible for an autosomal-dominantly inherited form of Parkinson's disease (PD) and α-synuclein was found to be the major component of Lewy bodies in PD. Because of the high homology to α-synuclein and the abundance in neuronal tissues, we investigated the γ-synuclein gene in PD. We analyzed 262 German PD patients and 179 healthy German controls via two polymorphisms in the γ-synuclein gene. No significant differences in the allelic or genotypic distributions of the investigated polymorphisms were observed between patients and controls. In addition no evidence for an increased risk of combined genotypes of polymorphisms in the γ-synuclein and the α-synuclein gene was found. Therefore, our results do not support a major role of the γ-synuclein gene in PD.",

keywords = "Genetics, Lewy body, Neurodegeneration, Parkinson's disease, Protein aggregation, α-synuclein, γ-synuclein",

author = "Rejko Kr{\"u}ger and Ludger Sch{\"o}ls and Thomas M{\"u}ller and Wilfried Kuhn and Dirk Woitalla and Horst Przuntek and Epplen, {J{\"o}rg T.} and Olaf Riess",

note = "Funding Information: We would like to thank numerous clinicians for providing blood samples of PD patients. This study has been supported by a FoRUM grant of the Faculty of Medicine of the Ruhr-University Bochum, Germany (to R.K.) and the BMBF MedNet program (to O.R.).",

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doi = "10.1016/S0304-3940(01)02127-9",

language = "English",

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T1 - Evaluation of the γ-synuclein gene in German Parkinson's disease patients

AU - Krüger, Rejko

AU - Schöls, Ludger

AU - Müller, Thomas

AU - Kuhn, Wilfried

AU - Woitalla, Dirk

AU - Przuntek, Horst

AU - Epplen, Jörg T.

AU - Riess, Olaf

N1 - Funding Information: We would like to thank numerous clinicians for providing blood samples of PD patients. This study has been supported by a FoRUM grant of the Faculty of Medicine of the Ruhr-University Bochum, Germany (to R.K.) and the BMBF MedNet program (to O.R.).

PY - 2001/9/14

Y1 - 2001/9/14

N2 - Mutations in the α-synuclein gene are responsible for an autosomal-dominantly inherited form of Parkinson's disease (PD) and α-synuclein was found to be the major component of Lewy bodies in PD. Because of the high homology to α-synuclein and the abundance in neuronal tissues, we investigated the γ-synuclein gene in PD. We analyzed 262 German PD patients and 179 healthy German controls via two polymorphisms in the γ-synuclein gene. No significant differences in the allelic or genotypic distributions of the investigated polymorphisms were observed between patients and controls. In addition no evidence for an increased risk of combined genotypes of polymorphisms in the γ-synuclein and the α-synuclein gene was found. Therefore, our results do not support a major role of the γ-synuclein gene in PD.

AB - Mutations in the α-synuclein gene are responsible for an autosomal-dominantly inherited form of Parkinson's disease (PD) and α-synuclein was found to be the major component of Lewy bodies in PD. Because of the high homology to α-synuclein and the abundance in neuronal tissues, we investigated the γ-synuclein gene in PD. We analyzed 262 German PD patients and 179 healthy German controls via two polymorphisms in the γ-synuclein gene. No significant differences in the allelic or genotypic distributions of the investigated polymorphisms were observed between patients and controls. In addition no evidence for an increased risk of combined genotypes of polymorphisms in the γ-synuclein and the α-synuclein gene was found. Therefore, our results do not support a major role of the γ-synuclein gene in PD.

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KW - Lewy body

KW - Neurodegeneration

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KW - Protein aggregation

KW - α-synuclein

KW - γ-synuclein

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JF - Neuroscience Letters

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Evaluation of the γ-synuclein gene in German Parkinson's disease patients

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