TY - JOUR
T1 - Etiology of viral respiratory infections in Northern Lao People's Democratic Republic
AU - Snoeck, Chantal J.
AU - Ponghsavath, Valy
AU - Luetteke, Nina
AU - Kaufmann, Sabine
AU - Sausy, Aurélie
AU - Samountry, Bounthome
AU - Jutavijittum, Prapan
AU - Weber, Bernard
AU - Muller, Claude P.
N1 - Funding Information:
The authors?thank the study volunteers for their participation and the staff from Luang Prabang Provincial Hospital for sample collection. They also thank S. Wolter and R. Sinner for their technical help. This study was supported by the Minist?re des Affaires ?trang?res et europ?ennes, Luxembourg and the Luxembourg Institute of Health through ?PaReCIDS? project.
Funding Information:
The authors thank the study volunteers for their participation and the staff from Luang Prabang Provincial Hospital for sample collection. They also thank S. Wolter and R. Sinner for their technical help. This study was supported by the Ministère des Affaires étrangères et européennes, Luxembourg and the Luxembourg Institute of Health through “PaReCIDS” project.
Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2018/10
Y1 - 2018/10
N2 - In Lao People's Democratic Republic (PDR), acute respiratory infections overburden the health care system, but viral etiology, genetic diversity, and seasonality, especially in light of the introduction of influenza vaccination in the country, are poorly understood. From August 2010 to April 2011, 309 outpatients were recruited at the Luang Prabang Provincial Hospital covering highland Lao communities. Nasopharyngeal swabs were screened for the presence of 13 respiratory viruses. At least one virus was detected in 69.6% and dual/triple viral infections in 12.9%/1.9% of the patients. Influenza A and B viruses combined were the most frequently detected pathogens, followed by human adenovirus and respiratory syncytial virus (RSV). The other viruses were detected in less than 10% of the patients. Phylogenetic analyses on a representative set of RSV strains revealed that, while otherwise very rare, the RSV-B CB1/THB genotype cocirculated with other common genotypes. A single wave of influenza virus and RSV activity was observed during the rainy season, providing further support to influenza vaccination before the onset of the rains. This study provides recommendations for influenza vaccination that still needs optimization and highlights the need for revised guidelines for treatment and prevention of respiratory infections in Lao PDR, as well as for increased surveillance efforts.
AB - In Lao People's Democratic Republic (PDR), acute respiratory infections overburden the health care system, but viral etiology, genetic diversity, and seasonality, especially in light of the introduction of influenza vaccination in the country, are poorly understood. From August 2010 to April 2011, 309 outpatients were recruited at the Luang Prabang Provincial Hospital covering highland Lao communities. Nasopharyngeal swabs were screened for the presence of 13 respiratory viruses. At least one virus was detected in 69.6% and dual/triple viral infections in 12.9%/1.9% of the patients. Influenza A and B viruses combined were the most frequently detected pathogens, followed by human adenovirus and respiratory syncytial virus (RSV). The other viruses were detected in less than 10% of the patients. Phylogenetic analyses on a representative set of RSV strains revealed that, while otherwise very rare, the RSV-B CB1/THB genotype cocirculated with other common genotypes. A single wave of influenza virus and RSV activity was observed during the rainy season, providing further support to influenza vaccination before the onset of the rains. This study provides recommendations for influenza vaccination that still needs optimization and highlights the need for revised guidelines for treatment and prevention of respiratory infections in Lao PDR, as well as for increased surveillance efforts.
KW - influenza virus
KW - respiratory syncytial virus
KW - respiratory tract
KW - seasonal incidence
UR - http://www.scopus.com/inward/record.url?scp=85050622452&partnerID=8YFLogxK
U2 - 10.1002/jmv.25237
DO - 10.1002/jmv.25237
M3 - Article
C2 - 29896913
AN - SCOPUS:85050622452
SN - 0146-6615
VL - 90
SP - 1553
EP - 1558
JO - Journal of Medical Virology
JF - Journal of Medical Virology
IS - 10
ER -