TY - JOUR
T1 - Estimated visceral adiposity is associated with risk of cardiometabolic conditions in a population based study
AU - Ruiz-Castell, Maria
AU - Samouda, Hanen
AU - Bocquet, Valery
AU - Fagherazzi, Guy
AU - Stranges, Saverio
AU - Huiart, Laetitia
N1 - Funding Information:
This work was supported by the National Research Fund of Luxembourg [C17/BM/11653863/iMPACT.lu to MRC], the Directorate and Ministry of Health and the Ministry of Higher Education and Research (MESR).
Funding Information:
We are grateful to the population of Luxembourg and to all the EHES-LUX team who have contributed to this study. We would like to thank Couffignal S, Kuemmerle A, Dincau M, Mormont D, Barre J, Chioti A, Delagardelle C, Michel G, Schlesser M, Schmit JC, Gantenbein M, Lieunard C, Columeau A, Kiemen M, Weis J, Ambroset G, Billy A, Larcelet M, Marcic D, Gauthier C, and Viau-Courville M for their valuable contributions. We would like to thank the national laboratory Ketterthill for the analysis of the biological samples. This research was funded by the National Research Fund of Luxembourg ([C17/BM/11653863/iMPACT.lu to MRC)], the Directorate and Ministry of Health, and the Ministry of Higher Education and Research (MESR).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Visceral adiposity is a major risk factor of cardiometabolic diseases. Visceral adipose tissue (VAT) is usually measured with expensive imaging techniques which present financial and practical challenges to population-based studies. We assessed whether cardiometabolic conditions were associated with VAT by using a new and easily measurable anthropometric index previously published and validated. Data (1529 participants) came from the European Health Examination Survey in Luxembourg (2013–2015). Logistic regressions were used to study associations between VAT and cardiometabolic conditions. We observed an increased risk of all conditions associated with VAT. The total adjusted odds ratio (AOR, [95% CI]) for hypertension, prediabetes/diabetes, hypercholesterolemia, and hypertriglyceridemia for the fourth quartile of VAT compared to the lowest were (10.67 [6.95, 16.39]), (6.14 [4.14, 9.10]), (6.03 [3.97, 9.16]) and (9.18 [5.97, 14.12]). We observed higher odds in women than in men for all outcomes with the exception of hypertension. Future studies should investigate the impact of VAT changes on cardiometabolic health and the use of anthropometrically predicted VAT as an accurate outcome when no biomedical imaging is available.
AB - Visceral adiposity is a major risk factor of cardiometabolic diseases. Visceral adipose tissue (VAT) is usually measured with expensive imaging techniques which present financial and practical challenges to population-based studies. We assessed whether cardiometabolic conditions were associated with VAT by using a new and easily measurable anthropometric index previously published and validated. Data (1529 participants) came from the European Health Examination Survey in Luxembourg (2013–2015). Logistic regressions were used to study associations between VAT and cardiometabolic conditions. We observed an increased risk of all conditions associated with VAT. The total adjusted odds ratio (AOR, [95% CI]) for hypertension, prediabetes/diabetes, hypercholesterolemia, and hypertriglyceridemia for the fourth quartile of VAT compared to the lowest were (10.67 [6.95, 16.39]), (6.14 [4.14, 9.10]), (6.03 [3.97, 9.16]) and (9.18 [5.97, 14.12]). We observed higher odds in women than in men for all outcomes with the exception of hypertension. Future studies should investigate the impact of VAT changes on cardiometabolic health and the use of anthropometrically predicted VAT as an accurate outcome when no biomedical imaging is available.
KW - Adult
KW - Cardiovascular Diseases/etiology
KW - Cross-Sectional Studies
KW - Diabetes Mellitus/etiology
KW - Female
KW - Humans
KW - Hypercholesterolemia/etiology
KW - Hypertension/etiology
KW - Hypertriglyceridemia/etiology
KW - Intra-Abdominal Fat/physiology
KW - Logistic Models
KW - Luxembourg
KW - Male
KW - Middle Aged
KW - Obesity, Abdominal/complications
KW - Prediabetic State/etiology
KW - Risk Factors
UR - http://www.scopus.com/inward/record.url?scp=85105072424&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/33907272
U2 - 10.1038/s41598-021-88587-9
DO - 10.1038/s41598-021-88587-9
M3 - Article
C2 - 33907272
AN - SCOPUS:85105072424
SN - 2045-2322
VL - 11
SP - 9121
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 9121
ER -