Erythema Induratum of Bazin: Evidence of T-Lymphocyte Hyperresponsiveness to Purified Protein Derivative of Tuberculin: Report of Two Cases and Treatment

Markus W. Ollert, Peter Thomas, Hans C. Korting*, Winfried Schraut, Otto Braun-Falco

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Abstract

Background and Design.—Erythema induratum of Bazin, a chronic form of nodular vasculitis, may be associated with chronic infections by Mycobacterium tuberculosis. However, the true origin of the disease is a subject of speculation and remains elusive. Two female patients (58 years old and 33 years old) with a minimum 10-year history of chronic tender ulcerating nodules on the lower aspects of the legs were studied both clinically and in the response of their peripheral T cells to purified protein derivative of tuberculin. Results.—Both patients with no previous history of tuberculosis had strongly positive skin test results at a Mantoux 10-4 dilution (1 unit of purified protein derivative). In response to full-course triple-agent (isoniazid, rifampicin, and ethambutol) chemotherapy, a complete remission of clinical symptoms was seen in both cases and no relapse occurred after discontinuation of therapy. A marked increase in peripheral T-lymphocyte response to purified protein derivative was found before onset of and during successful therapy. Conclusions.—The present clinical observations together with the pronounced cellular response to purified protein derivative suggest a tuberculous origin of erythema induratum of Bazin.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalArchives of Dermatology
Volume129
Issue number4
DOIs
Publication statusPublished - Apr 1993
Externally publishedYes

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