TY - JOUR
T1 - (Epi)transcriptomics in cardiovascular and neurological complications of COVID-19
AU - Jusic, Amela
AU - Stellos, Konstantinos
AU - Ferreira, Lino
AU - Baker, Andrew H.
AU - Devaux, Yvan
N1 - Funding
AJ is funded by the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 893435.
YD is funded by the EU Horizon 2020 project COVIRNA (Grant Agreement # 101016072), the National Research Fund (grants # C14/BM/ 8225223, C17/BM/11613033 and COVID-19/2020-1/14719577/ miRCOVID), the Ministry of Higher Education and Research, and the Heart Foundation-Daniel Wagner of Luxembourg.
KS is supported by grants from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (MODVASC, grant agreement No 759248) and the German Research Foundation DFG (SFB834 B12, project number 75732319).
LF is funded by the European Union's Horizon 2020 research and innovation program under grant agreement numbers 764958 (project NANOSTEM), 952266 (project RESETageing) and 101016072 (project COVIRNA), INTERREG program funding (Projects “NeuroAtlantic” and 2IQBioneuro, Ref: EAPA_791/2018 and Ref: 0624_2IQBIONEURO_6_E, respectively) and Portuguese Research Funds (project POCI-01-0145-FEDER-029229).
A.H.B is supported by the BHF Chair of Translational Cardiovascular Sciences (CH/11/2/28733), BHF programme grants (RG/14/3/30706, RG/20/5/34796 and RG/19/3/34265), BHF Centre for Vascular Regeneration and BHF Research Excellence Award RE/18/5/34216. He is also funded by the EU Horizon 2020 project COVIRNA (Grant Agreement # 101016072).
PY - 2022/9
Y1 - 2022/9
N2 - Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS-CoV-2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.
AB - Although systemic inflammation and pulmonary complications increase the mortality rate in COVID-19, a broad spectrum of cardiovascular and neurological complications can also contribute to significant morbidity and mortality. The molecular mechanisms underlying cardiovascular and neurological complications during and after SARS-CoV-2 infection are incompletely understood. Recently reported perturbations of the epitranscriptome of COVID-19 patients indicate that mechanisms including those derived from RNA modifications and non-coding RNAs may play a contributing role in the pathogenesis of COVID-19. In this review paper, we gathered recently published studies investigating (epi)transcriptomic fluctuations upon SARS-CoV-2 infection, focusing on the brain-heart axis since neurological and cardiovascular events and their sequelae are of utmost prevalence and importance in this disease.
KW - Brain-heart axis COVID-19 RNAs
UR - https://pubmed.ncbi.nlm.nih.gov/36164464
U2 - 10.1016/j.jmccpl.2022.100013
DO - 10.1016/j.jmccpl.2022.100013
M3 - Article
C2 - 36164464
SN - 2772-9761
VL - 1
JO - Journal of Molecular and Cellular Cardiology Plus
JF - Journal of Molecular and Cellular Cardiology Plus
M1 - 100013
ER -