Epitopes

C.P Muller, M Jacoby

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    T- and B-cell epitopes differ fundamentally in the way they are recognized by the immune system. B-cell epitopes are recognized as three-dimensional structures on the surface of native antigens. T-cell epitopes are parts of internalized and processed antigens that are presented to T lymphocytes in association with molecules of the major histocompatibility complex. Since in a biological system T- and B-cell receptors or antibody molecules face a virtual infinite number of structures, cognate interactions with epitopes are the basis of the primordial intelligence that drives the teleological choices of the immune system. Although theoretically any antigen comprises a myriad of potential epitopes, the immune response will focus only on a few of them by a phenomenon termed immunodominance. Understanding the mechanisms that govern epitope selection is important for epitope prediction and vaccine design.
    Original languageEnglish
    Title of host publicationEncyclopedia of Life Sciences (ELS)
    Place of PublicationChichester
    PublisherJohn Wiley & Sons Ltd
    Pages1-13
    Number of pages13
    ISBN (Print)9780470015902
    DOIs
    Publication statusPublished - 15 Sep 2009

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