TY - JOUR
T1 - Epidemiology of dementia in Central Africa (EPIDEMCA)
T2 - Protocol for a multicentre population-based study in rural and urban areas of the Central African Republic and the Republic of Congo
AU - Guerchet, Maëlenn
AU - Mbelesso, Pascal
AU - Ndamba-Bandzouzi, Bébène
AU - Pilleron, Sophie
AU - Desormais, Ileana
AU - Lacroix, Philippe
AU - Aboyans, Victor
AU - Jésus, Pierre
AU - Desport, Jean Claude
AU - Tchalla, Achille E.
AU - Marin, Benoît
AU - Lambert, Jean Charles
AU - Clément, Jean Pierre
AU - Dartigues, Jean François
AU - Preux, Pierre Marie
N1 - Funding Information:
This study was funded by a grant from the French National Research Agency (ANR-09-MNPS-009-01).
Funding Information:
-French National Research Agency (ANR) for funding this study through the ANR-09-MNPS-009-01 grant, -Universities of Bangui (CAR) and Marien Ngouabi in Brazzaville (Congo), as well as both Facultés des Sciences de la Santé in Bangui and Brazzaville, -Institut Pasteur in Bangui and Laboratoire National de Santé Publique in Brazzaville, -Health ministries of the Central African Republic and the Republic of Congo, for their moral support, -University of Limoges, Doctoral School of Limoges University, -Limousin Regional Council, -Town halls, mayors, and chiefs of districts of the 2 central African countries for their collaboration, -Investigators working for the programme, and staffs of Bangui and Brazzaville hospitals for their assistance, -All the elderly and their families who participated to these surveys.
PY - 2014
Y1 - 2014
N2 - Background: The worldwide population is ageing and the proportion of elderly aged 60 and over is expected to dramatically rise in Low and Middle Income Countries (LMIC). The epidemic of dementia will not spare those countries, where the largest increases in numbers of people affected are estimated. Besides, dementia is still understudied in sub-Saharan Africa (SSA) compared to other regions. This paper describes the protocol for the 'Epidemiology of Dementia in Central Africa' population-based study, which aims at estimating the prevalence of dementia in two countries of Central Africa and investigating possible risk factors. Methods/Design: A multicenter population-based study was carried out in Central African Republic and Republic of Congo between 2011 and 2012 including both urban and rural sites in each country. Around 2000 participants aged ≥65 years old were interviewed in total using the Community Screening Interview for Dementia (CSI-D), the GMS-AGECAT and the CERAD's 10-word list. Elderly with low performance to the cognitive part of the CSI-D (COGSCORE ≤ 24.5) were then clinically assessed by neurologists and underwent further psychometrical tests. DSM-IV and NINCDS-ADRDA criteria were required for dementia and Alzheimer's disease (AD) diagnoses respectively. The algorithmic 10/66 dementia diagnosis was also determined. Petersen's criteria were required for the diagnosis of Mild Cognitive Impairment. Sociodemographic, and environmental factors including vascular, nutritional, biological, psychosocial and lifestyle factors were collected in each setting in order to investigate factors associated with dementia. Blood sampling was realized to investigate genetic variations that could modify the risk of dementia. Discussion: For now, no large epidemiological study has been undertaken to compare the prevalence of dementia in both rural and urban areas within SSA countries. This programme will provide further evidence regarding the prevalence of dementia in SSA, and also the possible rural/urban disparities existing with associated factors. Furthermore, the genetics of AD in those populations will be addressed.
AB - Background: The worldwide population is ageing and the proportion of elderly aged 60 and over is expected to dramatically rise in Low and Middle Income Countries (LMIC). The epidemic of dementia will not spare those countries, where the largest increases in numbers of people affected are estimated. Besides, dementia is still understudied in sub-Saharan Africa (SSA) compared to other regions. This paper describes the protocol for the 'Epidemiology of Dementia in Central Africa' population-based study, which aims at estimating the prevalence of dementia in two countries of Central Africa and investigating possible risk factors. Methods/Design: A multicenter population-based study was carried out in Central African Republic and Republic of Congo between 2011 and 2012 including both urban and rural sites in each country. Around 2000 participants aged ≥65 years old were interviewed in total using the Community Screening Interview for Dementia (CSI-D), the GMS-AGECAT and the CERAD's 10-word list. Elderly with low performance to the cognitive part of the CSI-D (COGSCORE ≤ 24.5) were then clinically assessed by neurologists and underwent further psychometrical tests. DSM-IV and NINCDS-ADRDA criteria were required for dementia and Alzheimer's disease (AD) diagnoses respectively. The algorithmic 10/66 dementia diagnosis was also determined. Petersen's criteria were required for the diagnosis of Mild Cognitive Impairment. Sociodemographic, and environmental factors including vascular, nutritional, biological, psychosocial and lifestyle factors were collected in each setting in order to investigate factors associated with dementia. Blood sampling was realized to investigate genetic variations that could modify the risk of dementia. Discussion: For now, no large epidemiological study has been undertaken to compare the prevalence of dementia in both rural and urban areas within SSA countries. This programme will provide further evidence regarding the prevalence of dementia in SSA, and also the possible rural/urban disparities existing with associated factors. Furthermore, the genetics of AD in those populations will be addressed.
KW - Ageing
KW - Alzheimer's Disease
KW - Dementia
KW - Prevalence
KW - Risk Factors
KW - sub-Saharan Africa
UR - http://www.scopus.com/inward/record.url?scp=84928433436&partnerID=8YFLogxK
U2 - 10.1186/2193-1801-3-338
DO - 10.1186/2193-1801-3-338
M3 - Article
AN - SCOPUS:84928433436
SN - 2193-1801
VL - 3
SP - 1
EP - 12
JO - SpringerPlus
JF - SpringerPlus
IS - 1
M1 - 1044
ER -