Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones

Sandra Kuntz; Sabine Mazerbourg; Michel Boisbrun; Claudia Cerella; Marc Diederich; Isabelle Grillier-Vuissoz; Stephane Flament

doi:10.1016/j.bcp.2014.07.021

Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones

Sandra Kuntz, Sabine Mazerbourg, Michel Boisbrun, Claudia Cerella, Marc Diederich, Isabelle Grillier-Vuissoz, Stephane Flament^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

24 Citations (Scopus)

Abstract

The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ that were developed to treat type II diabetes. These compounds also display anticancer effects which appear mainly to be independent of their PPARγ agonist activity but the molecular mechanisms involved in the anticancer action are not yet well understood. Results obtained on ciglitazone derivatives, mainly in prostate cancer cell models, suggest that these compounds could act as ERMAs. In the present paper, we introduce how compounds like 2-deoxyglucose target the Warburg effect and then we discuss the possibility that the PPARγ-independent effects of various TZD could result from their action as ERMAs.

Original language	English
Pages (from-to)	102-111
Number of pages	10
Journal	Biochemical Pharmacology
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/j.bcp.2014.07.021
Publication status	Published - 1 Nov 2014
Externally published	Yes

Keywords

2-deoxyglucose, Thiazolidinediones
Cancer
Glucose metabolism
Warburg effect

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10.1016/j.bcp.2014.07.021

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title = "Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones",

abstract = "The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ that were developed to treat type II diabetes. These compounds also display anticancer effects which appear mainly to be independent of their PPARγ agonist activity but the molecular mechanisms involved in the anticancer action are not yet well understood. Results obtained on ciglitazone derivatives, mainly in prostate cancer cell models, suggest that these compounds could act as ERMAs. In the present paper, we introduce how compounds like 2-deoxyglucose target the Warburg effect and then we discuss the possibility that the PPARγ-independent effects of various TZD could result from their action as ERMAs.",

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T2 - Comparison between 2-deoxyglucose and thiazolidinediones

AU - Kuntz, Sandra

AU - Mazerbourg, Sabine

AU - Boisbrun, Michel

AU - Cerella, Claudia

AU - Diederich, Marc

AU - Grillier-Vuissoz, Isabelle

AU - Flament, Stephane

PY - 2014/11/1

Y1 - 2014/11/1

N2 - The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ that were developed to treat type II diabetes. These compounds also display anticancer effects which appear mainly to be independent of their PPARγ agonist activity but the molecular mechanisms involved in the anticancer action are not yet well understood. Results obtained on ciglitazone derivatives, mainly in prostate cancer cell models, suggest that these compounds could act as ERMAs. In the present paper, we introduce how compounds like 2-deoxyglucose target the Warburg effect and then we discuss the possibility that the PPARγ-independent effects of various TZD could result from their action as ERMAs.

AB - The use of energy restriction mimetic agents (ERMAs) to selectively target cancer cells addicted to glycolysis could be a promising therapeutic approach. Thiazolidinediones (TZDs) are synthetic agonists of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ that were developed to treat type II diabetes. These compounds also display anticancer effects which appear mainly to be independent of their PPARγ agonist activity but the molecular mechanisms involved in the anticancer action are not yet well understood. Results obtained on ciglitazone derivatives, mainly in prostate cancer cell models, suggest that these compounds could act as ERMAs. In the present paper, we introduce how compounds like 2-deoxyglucose target the Warburg effect and then we discuss the possibility that the PPARγ-independent effects of various TZD could result from their action as ERMAs.

KW - 2-deoxyglucose, Thiazolidinediones

KW - Cancer

KW - Glucose metabolism

KW - Warburg effect

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ER -

Energy restriction mimetic agents to target cancer cells: Comparison between 2-deoxyglucose and thiazolidinediones

Abstract

Keywords

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