Endothelial cell hypertrophy and microvascular proliferation in meningiomas are correlated with higher histological grade and shorter progression-free survival

Catherine Ling, Celso Pouget, Fabien Rech, Robin Pflaum, Mathilde Treffel, Franck Bielle, Karima Mokhtari, Jean Matthieu Casse, Jean Michel Vignaud, Michel Kalamarides, Matthieu Peyre, Guillaume Gauchotte*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Microvascular proliferation (MVP) is a hallmark of glioblastoma. Endothelial cell hypertrophy (ECH), also known as endothelial hyperplasia, is correlated with a shorter survival of patients with gliomas. However, the prognostic value of these 2 morphological features has not been studied in meningiomas. The aim of this study was to evaluate the prognostic value of angiogenesis in meningiomas, most notably ECH, MVP, and microvascular density, which were evaluated using immunohistochemistry with antibodies against CD34 and CD105 (a marker of neovascularization) in a series of 139 meningiomas. ECH, MVP, and CD105 immunoreactivity were significantly correlated with higher histological grades (p < 0.0001, p=0.0004, and p=0.0003, respectively). ECH and MVP but not CD105 immunoreactivities were significantly correlated with a shorter progression-free survival time (PFS) (p=0.017, p=0.021, and p=0.137, respectively). In Cox multivariate analysis, ECH was an independent predictor of shorter PFS (p=0.028). Therefore, ECH and MVP are markers of shorter PFS in meningiomas and are significantly correlated with grade. These findings give insight into the use of anti-angiogenic therapies. Further studies are needed to determine whether these markers could allow us to identify patients who could benefit from anti-angiogenic therapies.

Original languageEnglish
Pages (from-to)1160-1170
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume75
Issue number12
DOIs
Publication statusPublished - 1 Dec 2016
Externally publishedYes

Keywords

  • CD105
  • CD34
  • Endothelial cell hypertrophy
  • Meningioma
  • Microvascular proliferation
  • Microvessel density
  • Vascularization

Fingerprint

Dive into the research topics of 'Endothelial cell hypertrophy and microvascular proliferation in meningiomas are correlated with higher histological grade and shorter progression-free survival'. Together they form a unique fingerprint.

Cite this