Empfehlung zum differenzierten Einsatz nuklearmedizinischer Diagnostik bei Parkinson-Syndromen

Translated title of the contribution: Recommendation for the differentiated use of nuclear medical diagnostic for parkinsonian syndromes

Thilo Van Eimeren*, Joseph Claßen, Alexander Drzezga, Carsten Eggers, Rüdiger Hilker-Roggendorf, Jochen Klucken, Jiri Koschel, Philipp Tobias Meyer, Christoph Redecker, Hendrik Theis, Carsten Buhmann

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The present work provides an overview of the various nuclear medicine methods in the diagnosis of neurodegenerative parkinsonian syndromes and their respective evidence and is intended to enable practical decision-making aids in the application and interpretation of the methods and findings. The value of the procedures differs considerably in relation to the two relevant diagnostic questions. On the one hand, it is the question of whether there is a neurodegenerative parkinsonian syndrome at all, and on the other hand the question of which one. While the DAT-SPECT is undisputedly the method of choice for answering the first question (taking certain parameters into account), this method is not suitable for answering the second question. To categorise parkinsonian syndromes into idiopathic (i. e. Parkinson's disease) or atypical, various procedures are used in everyday clinical practice including MIBG scintigraphy, and FDG-PET. We explain why FDG-PET currently is not only the most suitable of these methods to differentiate an idiopathic parkinsonian syndrome, from an atypical Parkinson's syndrome, but also enables sufficiently valid to distinguish the various atypical neurodegenerative Parkinson's syndromes (i. e. MSA, PSP and CBD) from each other and therefore should be reimbursed by health insurances.

Translated title of the contributionRecommendation for the differentiated use of nuclear medical diagnostic for parkinsonian syndromes
Original languageGerman
Pages (from-to)609-619
Number of pages11
JournalFortschritte der Neurologie Psychiatrie
Volume88
Issue number9
DOIs
Publication statusPublished - 1 Sep 2020
Externally publishedYes

Keywords

  • atypical
  • DAT-SPECT
  • FDG-PET
  • idiopathic
  • nuclear medicine
  • Parkinsonian syndrome

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