Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells

Michel Mittelbronn; Perikles Simon; Christian Löffler; David Capper; Benedikt Bunz; Patrick Harter; Holger Schlaszus; Ariane Schleich; Ghazaleh Tabatabai; Benjamin Goeppert; Richard Meyermann; Michael Weller; Jörg Wischhusen

doi:10.1016/j.jneuroim.2007.07.002

Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8⁺ cells

Michel Mittelbronn^*
, Perikles Simon
, Christian Löffler
, David Capper
, Benedikt Bunz
, Patrick Harter
, Holger Schlaszus
, Ariane Schleich
, Ghazaleh Tabatabai
, Benjamin Goeppert
, Richard Meyermann
, Michael Weller
, Jörg Wischhusen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

54 Citations (Scopus)

Abstract

HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8⁺ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.

Original language	English
Pages (from-to)	50-58
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	189
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.07.002
Publication status	Published - Sept 2007
Externally published	Yes

Keywords

CD8
Cytotoxic T cells
HLA-E
Human astrocytomas
Immune escape
NK cells

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10.1016/j.jneuroim.2007.07.002

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Mittelbronn, M., Simon, P., Löffler, C., Capper, D., Bunz, B., Harter, P., Schlaszus, H., Schleich, A., Tabatabai, G., Goeppert, B., Meyermann, R., Weller, M., & Wischhusen, J. (2007). Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8⁺ cells. Journal of Neuroimmunology, 189(1-2), 50-58. https://doi.org/10.1016/j.jneuroim.2007.07.002

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title = "Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells",

abstract = "HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8+ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.",

keywords = "CD8, Cytotoxic T cells, HLA-E, Human astrocytomas, Immune escape, NK cells",

author = "Michel Mittelbronn and Perikles Simon and Christian L{\"o}ffler and David Capper and Benedikt Bunz and Patrick Harter and Holger Schlaszus and Ariane Schleich and Ghazaleh Tabatabai and Benjamin Goeppert and Richard Meyermann and Michael Weller and J{\"o}rg Wischhusen",

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doi = "10.1016/j.jneuroim.2007.07.002",

language = "English",

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Mittelbronn, M, Simon, P, Löffler, C, Capper, D, Bunz, B, Harter, P, Schlaszus, H, Schleich, A, Tabatabai, G, Goeppert, B, Meyermann, R, Weller, M & Wischhusen, J 2007, 'Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8⁺ cells', Journal of Neuroimmunology, vol. 189, no. 1-2, pp. 50-58. https://doi.org/10.1016/j.jneuroim.2007.07.002

TY - JOUR

T1 - Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells

AU - Mittelbronn, Michel

AU - Simon, Perikles

AU - Löffler, Christian

AU - Capper, David

AU - Bunz, Benedikt

AU - Harter, Patrick

AU - Schlaszus, Holger

AU - Schleich, Ariane

AU - Tabatabai, Ghazaleh

AU - Goeppert, Benjamin

AU - Meyermann, Richard

AU - Weller, Michael

AU - Wischhusen, Jörg

PY - 2007/9

Y1 - 2007/9

N2 - HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8+ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.

AB - HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8+ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.

KW - CD8

KW - Cytotoxic T cells

KW - HLA-E

KW - Human astrocytomas

KW - Immune escape

KW - NK cells

UR - https://www.scopus.com/pages/publications/34548496304

U2 - 10.1016/j.jneuroim.2007.07.002

DO - 10.1016/j.jneuroim.2007.07.002

M3 - Article

C2 - 17675252

AN - SCOPUS:34548496304

SN - 0165-5728

VL - 189

SP - 50

EP - 58

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8⁺ cells

Abstract

Keywords

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