Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells

Michel Mittelbronn*, Perikles Simon, Christian Löffler, David Capper, Benedikt Bunz, Patrick Harter, Holger Schlaszus, Ariane Schleich, Ghazaleh Tabatabai, Benjamin Goeppert, Richard Meyermann, Michael Weller, Jörg Wischhusen

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Abstract

HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8+ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.

Original languageEnglish
Pages (from-to)50-58
Number of pages9
JournalJournal of Neuroimmunology
Volume189
Issue number1-2
DOIs
Publication statusPublished - Sep 2007
Externally publishedYes

Keywords

  • CD8
  • Cytotoxic T cells
  • HLA-E
  • Human astrocytomas
  • Immune escape
  • NK cells

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