Elevated CD3+ and CD8+ tumor-infiltrating immune cells correlate with prolonged survival in glioblastoma patients despite integrated immunosuppressive mechanisms in the tumor microenvironment and at the systemic level

Justyna Kmiecik, Aurélie Poli, Nicolaas H.C. Brons, Andreas Waha, Geir Egil Eide, Per Øyvind Enger, Jacques Zimmer, Martha Chekenya*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

232 Citations (Scopus)

Abstract

We characterized GBM patients' tumor and systemic immune contexture with aim to reveal the mechanisms of immunological escape, their impact on patient outcome, and identify targets for immunotherapy. Increased CD3+ T-cell infiltration was associated with prolonged survival independent of age, MGMT promoter methylation and post-operative treatment that implies potential for immunotherapy for GBM. Several mechanisms of escape were identified: within the tumor microenvironment: induced CD8+CD28-Foxp3+ Tregs that may tolerize antigen presenting cells, elevated CD73 and CD39 ectonucleotidases that suppress T-cell function, and at the systemic level: elevated IL-10 levels in serum, diminished helper T-cell counts, and upregulated inhibitory CTLA-4.

Original languageEnglish
Pages (from-to)71-83
Number of pages13
JournalJournal of Neuroimmunology
Volume264
Issue number1-2
DOIs
Publication statusPublished - 2013

Keywords

  • Antigen presenting cells
  • GBM
  • Regulatory T cells
  • Tumor infiltrating cells

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