Effects of natural products on Mcl-1 expression and function

Florian Muller; Claudia Cerella; Flavia Radogna; Mario Dicato; Marc Diederich

doi:10.2174/0929867322666150716115435

Effects of natural products on Mcl-1 expression and function

Florian Muller, Claudia Cerella, Flavia Radogna, Mario Dicato, Marc Diederich^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.

Original language	English
Pages (from-to)	3447-3461
Number of pages	15
Journal	Current Medicinal Chemistry
Volume	22
Issue number	30
DOIs	https://doi.org/10.2174/0929867322666150716115435
Publication status	Published - 1 Nov 2015
Externally published	Yes

Keywords

Apoptosis
Cancer
Mcl-1
Natural compounds

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10.2174/0929867322666150716115435

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title = "Effects of natural products on Mcl-1 expression and function",

abstract = "Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.",

keywords = "Apoptosis, Cancer, Mcl-1, Natural compounds",

author = "Florian Muller and Claudia Cerella and Flavia Radogna and Mario Dicato and Marc Diederich",

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AU - Muller, Florian

AU - Cerella, Claudia

AU - Radogna, Flavia

AU - Dicato, Mario

AU - Diederich, Marc

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.

AB - Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.

KW - Apoptosis

KW - Cancer

KW - Mcl-1

KW - Natural compounds

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SP - 3447

EP - 3461

JO - Current Medicinal Chemistry

JF - Current Medicinal Chemistry

IS - 30

ER -

Effects of natural products on Mcl-1 expression and function

Abstract

Keywords

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