Effects of Minocycline Hydrochloride as an Adjuvant Therapy for a Guided Bone Augmentation Procedure in The Rat Calvarium

Bob Biewer*, Eric Rompen, Michel Mittelbronn, Gaël P. Hammer, Pascale Quatresooz, Felix Kleine Borgmann

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This in vivo study reports the influence of minocycline-HCl administration on extra-skeletal bone generation in a Guided Bone Augmentation model, utilizing titanium caps placed on the intact as well as perforated calvaria of rats. The test group was administered 0.5 mg/mL minocycline-HCl with the drinking water, and the amount of bone tissue in the caps was quantified at three time points (4, 8 and 16 weeks). A continuously increased tissue fill was observed in all groups over time. The administration of minocycline-HCl as well as perforation of the calvaria increased this effect, especially with regard to mineralization. The strongest tissue augmentation, with 1.8 times that of the untreated control group, and, at the same time, the most mineralized tissue (2.3× over untreated control), was produced in the combination of both treatments, indicating that systemic administration of minocycline-HCl has an accelerating and enhancing effect on vertical bone augmentation.

Original languageEnglish
Article number92
JournalDentistry Journal
Volume11
Issue number4
DOIs
Publication statusPublished - 31 Mar 2023

Keywords

  • cortical perforation
  • guided bone regeneration
  • minocycline
  • vertical bone augmentation

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