TY - JOUR
T1 - Effects of Minocycline Hydrochloride as an Adjuvant Therapy for a Guided Bone Augmentation Procedure in The Rat Calvarium
AU - Biewer, Bob
AU - Rompen, Eric
AU - Mittelbronn, Michel
AU - Hammer, Gaël P.
AU - Quatresooz, Pascale
AU - Borgmann, Felix Kleine
N1 - Funding Information:
Luxembourg National Research Fund (FNR) PEARL grant to M.M.
Publisher Copyright:
© 2023 by the authors.
PY - 2023/3/31
Y1 - 2023/3/31
N2 - This in vivo study reports the influence of minocycline-HCl administration on extra-skeletal bone generation in a Guided Bone Augmentation model, utilizing titanium caps placed on the intact as well as perforated calvaria of rats. The test group was administered 0.5 mg/mL minocycline-HCl with the drinking water, and the amount of bone tissue in the caps was quantified at three time points (4, 8 and 16 weeks). A continuously increased tissue fill was observed in all groups over time. The administration of minocycline-HCl as well as perforation of the calvaria increased this effect, especially with regard to mineralization. The strongest tissue augmentation, with 1.8 times that of the untreated control group, and, at the same time, the most mineralized tissue (2.3× over untreated control), was produced in the combination of both treatments, indicating that systemic administration of minocycline-HCl has an accelerating and enhancing effect on vertical bone augmentation.
AB - This in vivo study reports the influence of minocycline-HCl administration on extra-skeletal bone generation in a Guided Bone Augmentation model, utilizing titanium caps placed on the intact as well as perforated calvaria of rats. The test group was administered 0.5 mg/mL minocycline-HCl with the drinking water, and the amount of bone tissue in the caps was quantified at three time points (4, 8 and 16 weeks). A continuously increased tissue fill was observed in all groups over time. The administration of minocycline-HCl as well as perforation of the calvaria increased this effect, especially with regard to mineralization. The strongest tissue augmentation, with 1.8 times that of the untreated control group, and, at the same time, the most mineralized tissue (2.3× over untreated control), was produced in the combination of both treatments, indicating that systemic administration of minocycline-HCl has an accelerating and enhancing effect on vertical bone augmentation.
KW - cortical perforation
KW - guided bone regeneration
KW - minocycline
KW - vertical bone augmentation
UR - http://www.scopus.com/inward/record.url?scp=85153741432&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37185470
U2 - 10.3390/dj11040092
DO - 10.3390/dj11040092
M3 - Article
C2 - 37185470
SN - 2304-6767
VL - 11
JO - Dentistry Journal
JF - Dentistry Journal
IS - 4
M1 - 92
ER -