TY - JOUR
T1 - Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice
AU - Gantenbein, M.
AU - Attolini, L.
AU - Bruguerolle, B.
N1 - Funding Information:
This work was partly supportedb y a grant from DGRST (ER 3 11) Aix-Marseilles II University Faculty of Medicine of Marseilles, France. The authorsw ish to thank Leo Labs., Merck Labs. and Smith Kline BeechamL abs for the gift of Pinacidil, Nicorandil and Levcromakalim, respectively. Special thankst o J. Mouchet for technicala ssistance.
PY - 1995/7/28
Y1 - 1995/7/28
N2 - The influence of four potassium channel agonists I.E. Diazoxide (D), levcromakalim (L), nicorandil (N) and pinacidil (P) on bupivacaine-induced acute toxicity was evaluated by measuring the convulsant activity, the time of latency to convulse and the mortality rate. Four different dosages (i.e. 0.1,1, 10 and 100 mg/kg/i.p. for D, N and P and 0.01, 0.1, 1 and 5 mg/kg/i.p. for L) were injected to a total of 200 male NMRI adult mice: 16 groups of 10 mice each were previously treated by a single I.P. Dose of each potassium channel agonist while controls (n = 40) received saline injection. Thus, 15 minutes later, all groups were injected with a 50 mg/kg/i.p. single dose of bupivacaine. The convulsant activity of bupivacaine was significantly modified by only high doses of L in a dosedependent manner. Compared to the controls, the period of latency was significantly increased for most of the doses of P, N, D and L in a dose dependent manner for L and P. The anesthetic-induced mortality (47.5 % for controls) was not significantly modified by D, but decreased by N and increased by high doses of L and P which is probably related to a delayed mortality.
AB - The influence of four potassium channel agonists I.E. Diazoxide (D), levcromakalim (L), nicorandil (N) and pinacidil (P) on bupivacaine-induced acute toxicity was evaluated by measuring the convulsant activity, the time of latency to convulse and the mortality rate. Four different dosages (i.e. 0.1,1, 10 and 100 mg/kg/i.p. for D, N and P and 0.01, 0.1, 1 and 5 mg/kg/i.p. for L) were injected to a total of 200 male NMRI adult mice: 16 groups of 10 mice each were previously treated by a single I.P. Dose of each potassium channel agonist while controls (n = 40) received saline injection. Thus, 15 minutes later, all groups were injected with a 50 mg/kg/i.p. single dose of bupivacaine. The convulsant activity of bupivacaine was significantly modified by only high doses of L in a dosedependent manner. Compared to the controls, the period of latency was significantly increased for most of the doses of P, N, D and L in a dose dependent manner for L and P. The anesthetic-induced mortality (47.5 % for controls) was not significantly modified by D, but decreased by N and increased by high doses of L and P which is probably related to a delayed mortality.
KW - bupivacaine
KW - local anesthetics
KW - potassium channel agonists
KW - toxicity
UR - http://www.scopus.com/inward/record.url?scp=0029023876&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(95)02039-L
DO - 10.1016/0024-3205(95)02039-L
M3 - Article
C2 - 7643714
AN - SCOPUS:0029023876
SN - 0024-3205
VL - 57
SP - PL113-PL116
JO - Life Sciences
JF - Life Sciences
IS - 10
ER -