TY - JOUR
T1 - Early-life adversity leaves its imprint on the oral microbiome for more than 20 years and is associated with long-term immune changes
AU - Charalambous, Eleftheria G.
AU - Mériaux, Sophie B.
AU - Guebels, Pauline
AU - Muller, Claude P.
AU - Leenen, Fleur A.D.
AU - Elwenspoek, Martha M.C.
AU - Thiele, Ines
AU - Hertel, Johannes
AU - Turner, Jonathan D.
N1 - Funding Information:
Funding: E.G.C. is currently funded by the FNR (PRIDE/11823097/MICROH). The work of J.D.T. on the long-term consequences of ELA was further funded by FNR-CORE (C16/BM/11342695 “Met-COEPs” and C12/BM/3985792 “EpiPath”) and FNR-INTER (INTER/ANR/16/11568350 “MADAM”). J.D.T. is a management committee member of the EU-funded COST action CA18211 focused on early-life and birth-associated trauma. J.H. and I.T. were funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No. 757922) to I.T. The APC was funded by the Fonds National de Recherche, Luxembourg.
Funding Information:
E.G.C. is currently funded by the FNR (PRIDE/11823097/MICROH). The work of J.D.T. on the long-term consequences of ELA was further funded by FNR-CORE (C16/BM/11342695 ?Met-COEPs? and C12/BM/3985792 ?EpiPath?) and FNR-INTER (INTER/ANR/16/11568350 ?MADAM?). J.D.T. is a management committee member of the EU-funded COST action CA18211 focused on early-life and birth-associated trauma. J.H. and I.T. were funded by the European Research Council (ERC) under the European Union?s Horizon 2020 research and innovation programme (grant agreement No. 757922) to I.T. The APC was funded by the Fonds National de Recherche, Luxembourg.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11/24
Y1 - 2021/11/24
N2 - The early-life microbiome (ELM) interacts with the psychosocial environment, in partic-ular during early-life adversity (ELA), defining life-long health trajectories. The ELM also plays a significant role in the maturation of the immune system. We hypothesised that, in this context, the resilience of the oral microbiomes, despite being composed of diverse and distinct communities, allows them to retain an imprint of the early environment. Using 16S amplicon sequencing on the EpiPath cohort, we demonstrate that ELA leaves an imprint on both the salivary and buccal oral microbiome 24 years after exposure to adversity. Furthermore, the changes in both communities were associated with increased activation, maturation, and senescence of both innate and adaptive immune cells, although the interaction was partly dependent on prior herpesviridae exposure and current smoking. Our data suggest the presence of multiple links between ELA, Immunosenescence, and cytotoxicity that occur through long-term changes in the microbiome.
AB - The early-life microbiome (ELM) interacts with the psychosocial environment, in partic-ular during early-life adversity (ELA), defining life-long health trajectories. The ELM also plays a significant role in the maturation of the immune system. We hypothesised that, in this context, the resilience of the oral microbiomes, despite being composed of diverse and distinct communities, allows them to retain an imprint of the early environment. Using 16S amplicon sequencing on the EpiPath cohort, we demonstrate that ELA leaves an imprint on both the salivary and buccal oral microbiome 24 years after exposure to adversity. Furthermore, the changes in both communities were associated with increased activation, maturation, and senescence of both innate and adaptive immune cells, although the interaction was partly dependent on prior herpesviridae exposure and current smoking. Our data suggest the presence of multiple links between ELA, Immunosenescence, and cytotoxicity that occur through long-term changes in the microbiome.
KW - Bacterial community
KW - Developmental origins of health and disease
KW - Early experience
KW - Early-life adversity
KW - Host-microbe interactions
KW - Immune system
KW - Microbiome
KW - Oral microbiome
UR - http://www.scopus.com/inward/record.url?scp=85119652084&partnerID=8YFLogxK
UR - https://www.ncbi.nlm.nih.gov/pubmed/34884490
U2 - 10.3390/ijms222312682
DO - 10.3390/ijms222312682
M3 - Article
C2 - 34884490
AN - SCOPUS:85119652084
SN - 1661-6596
VL - 22
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 23
M1 - 12682
ER -