Dynamics of the reactivity to MBP in multiple sclerosis

Antonio Uccelli*, Giovanni Ristori, Debora Giunti, Marco Seri, Chiara Montesperelli, Francesco Caroli, Claudio Solaro, Alessandra Murialdo, Monica Marchese, Caria Buttinelli, Gianluigi Mancardi, Marco Salvetti

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


Though many lines of evidence support the importance of myelin basic protein (MBP) in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), its role in multiple sclerosis (MS) is still debated as well as the significance of epitope spreading in disease progression. We characterised the response to MBP in eight MS subjects and three of these were followed over time. In one case, the follow up lasted over a 6-year period. Clonal expansion, clonal persistence and epitope spreading against other MBP determinants was detected irrespective of disease course. In one patient we identified a novel T-cell receptor variable gene (BV28S2) which may be involved in the selection of MBP determinants, as suggested by experiments performed in the presence of mismatched antigen presenting cells (APC) between two subjects compatible for HLA-DR2 subtype but differing for the epitope recognised. Our findings do not sustain a role for the response to MBP effecting on clinical course and suggest that a novel TCR gene may be involved in the recognition of unusual self antigens.

Original languageEnglish
Pages (from-to)S52-S56
JournalJournal of NeuroVirology
Issue numberSUPPL. 2
Publication statusPublished - 2000
Externally publishedYes


  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Myelin basic protein
  • T-cell receptor


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