Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter

Ivanna K. Timotius, Fabio Canneva, Georgia Minakaki, Cristian Pasluosta, Sandra Moceri, Nicolas Casadei, Olaf Riess, Jürgen Winkler, Jochen Klucken, Stephan von Hörsten*, Bjoern Eskofier

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


Background Sway is a crucial gait characteristic tightly correlated with the risk of falling in patients with Parkinsońs disease (PD). So far, the swaying pattern during locomotion has not been investigated in rodent models using the analysis of dynamic footprint recording obtained from the CatWalk gait recording and analysis system. New methods We present three methods for describing locomotion sway and apply them to footprint recordings taken from C57BL6/N wild-type mice and two different α-synuclein transgenic PD-relevant mouse models (α-syn m -ko, α-syn m -koxα-syn h -tg). Individual locomotion data were subjected to three different signal processing analytical approaches: the first two methods are based on Fast Fourier Transform (FFT), while the third method uses Low Pass Filters (LPF). These methods use the information associated with the locomotion sway and generate sway-related parameters. Results The three proposed methods were successfully applied to the footprint recordings taken from all paws as well as from front/hind-paws separately. Nine resulting sway-related parameters were generated and successfully applied to differentiate between the mouse models under study. Namely, α-synucleinopathic mice revealed higher sway and sway itself was significantly higher in the α-syn m -koxα-syn h -tg mice compared to their wild-type littermates in eight of the nine sway-related parameters. Comparison with existing method Previous locomotion sway index computation is based on the estimated center of mass position of mice. Conclusions The methods presented in this study provide a sway-related gait characterization. Their application is straightforward and may lead to the identification of gait pattern derived biomarkers in rodent models of PD.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJournal of Neuroscience Methods
Publication statusPublished - 15 Feb 2018
Externally publishedYes


  • Alpha-synuclein transgenic
  • CatWalk system
  • Gait analysis
  • Locomotion
  • Parkinson's disease
  • Sway


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