Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

Marina Wierz; Sandrine Pierson; Léa Guyonnet; Elodie Viry; Audrey Lequeux; Anaïs Oudin; Simone P. Niclou; Markus Ollert; Guy Berchem; Bassam Janji; Coralie Guérin; Jerome Paggetti; Etienne Moussay

doi:10.1182/blood-2017-06-792267

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

Marina Wierz, Sandrine Pierson, Léa Guyonnet, Elodie Viry, Audrey Lequeux, Anaïs Oudin, Simone P. Niclou, Markus Ollert, Guy Berchem, Bassam Janji, Coralie Guérin, Jerome Paggetti^* (Main author), Etienne Moussay

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

105 Citations (Scopus)

Original language	English
Pages (from-to)	1617-1621
Number of pages	5
Journal	Blood
Volume	131
Issue number	14
DOIs	https://doi.org/10.1182/blood-2017-06-792267
Publication status	Published - 5 Apr 2018

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10.1182/blood-2017-06-792267

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@article{1b8521a80ea24c8b9a0b3ae33f306ecb,

title = "Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia",

author = "Marina Wierz and Sandrine Pierson and L{\'e}a Guyonnet and Elodie Viry and Audrey Lequeux and Ana{\"i}s Oudin and Niclou, {Simone P.} and Markus Ollert and Guy Berchem and Bassam Janji and Coralie Gu{\'e}rin and Jerome Paggetti and Etienne Moussay",

note = "Funding Information: This project was supported by T{\'e}l{\'e}vie (grants 7.4563.15, 7.4508.16, and 7.4571.15), the Luxembourg Institute of Health (HEMATEXO project), and the Luxembourg National Research Fund (FNR) PRIDE program grant 11012546/NEXTIMMUNE (M.O.). The National Cytometry Platform at the Luxembourg Institute of Health received funding by the European Regional Development Fund (F.E.D.E.R.) for the CyTOF instrument. Funding Information: The authors thank Dominique Revets (National Cytometry Platform, Luxembourg Institute of Health) and Petr Nazarov (Proteome and Genome Research Unit, Luxembourg Institute of Health) for their technical help. They also thank Carlo Croce and John Byrd (Ohio State University) for the kind gift of Em-TCL1 mouse and Martina Seiffert (DKFZ Heidelberg, Germany) for providing animals. Finally we thank Joshua Brown-Clay (Luxembourg Institute of Health) for editing the manuscript. This project was supported by T?l?vie (grants 7.4563.15, 7.4508.16, and 7.4571.15), the Luxembourg Institute of Health (HEMATEXO project), and the Luxembourg National Research Fund (FNR) PRIDE program grant 11012546/NEXTIMMUNE (M.O.). The National Cytometry Platform at the Luxembourg Institute of Health received funding by the European Regional Development Fund (F.E.D.E.R.) for the CyTOF instrument. Funding Information: The authors thank Dominique Revets (National Cytometry Platform, Luxembourg Institute of Health) and Petr Nazarov (Proteome and Genome Research Unit, Luxembourg Institute of Health) for their technical help. They also thank Carlo Croce and John Byrd (Ohio State University) for the kind gift of Em-TCL1 mouse and Martina Seiffert (DKFZ Heidelberg, Germany) for providing animals. Finally we thank Joshua Brown-Clay (Luxembourg Institute of Health) for editing the manuscript. This project was supported by T{\'e}l{\'e}vie (grants 7.4563.15, 7.4508.16, and 7.4571.15), the Luxembourg Institute of Health (HEMATEXO project), and the Luxembourg National Research Fund (FNR) PRIDE program grant 11012546/NEXTIMMUNE (M.O.). The National Cytometry Platform at the Luxembourg Institute of Health received funding by the European Regional Development Fund (F.E.D.E.R.) for the CyTOF instrument.",

year = "2018",

month = apr,

day = "5",

doi = "10.1182/blood-2017-06-792267",

language = "English",

volume = "131",

pages = "1617--1621",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier BV",

number = "14",

}

TY - JOUR

T1 - Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

AU - Wierz, Marina

AU - Pierson, Sandrine

AU - Guyonnet, Léa

AU - Viry, Elodie

AU - Lequeux, Audrey

AU - Oudin, Anaïs

AU - Niclou, Simone P.

AU - Ollert, Markus

AU - Berchem, Guy

AU - Janji, Bassam

AU - Guérin, Coralie

AU - Paggetti, Jerome

AU - Moussay, Etienne

N1 - Funding Information: This project was supported by Télévie (grants 7.4563.15, 7.4508.16, and 7.4571.15), the Luxembourg Institute of Health (HEMATEXO project), and the Luxembourg National Research Fund (FNR) PRIDE program grant 11012546/NEXTIMMUNE (M.O.). The National Cytometry Platform at the Luxembourg Institute of Health received funding by the European Regional Development Fund (F.E.D.E.R.) for the CyTOF instrument. Funding Information: The authors thank Dominique Revets (National Cytometry Platform, Luxembourg Institute of Health) and Petr Nazarov (Proteome and Genome Research Unit, Luxembourg Institute of Health) for their technical help. They also thank Carlo Croce and John Byrd (Ohio State University) for the kind gift of Em-TCL1 mouse and Martina Seiffert (DKFZ Heidelberg, Germany) for providing animals. Finally we thank Joshua Brown-Clay (Luxembourg Institute of Health) for editing the manuscript. This project was supported by T?l?vie (grants 7.4563.15, 7.4508.16, and 7.4571.15), the Luxembourg Institute of Health (HEMATEXO project), and the Luxembourg National Research Fund (FNR) PRIDE program grant 11012546/NEXTIMMUNE (M.O.). The National Cytometry Platform at the Luxembourg Institute of Health received funding by the European Regional Development Fund (F.E.D.E.R.) for the CyTOF instrument. Funding Information: The authors thank Dominique Revets (National Cytometry Platform, Luxembourg Institute of Health) and Petr Nazarov (Proteome and Genome Research Unit, Luxembourg Institute of Health) for their technical help. They also thank Carlo Croce and John Byrd (Ohio State University) for the kind gift of Em-TCL1 mouse and Martina Seiffert (DKFZ Heidelberg, Germany) for providing animals. Finally we thank Joshua Brown-Clay (Luxembourg Institute of Health) for editing the manuscript. This project was supported by Télévie (grants 7.4563.15, 7.4508.16, and 7.4571.15), the Luxembourg Institute of Health (HEMATEXO project), and the Luxembourg National Research Fund (FNR) PRIDE program grant 11012546/NEXTIMMUNE (M.O.). The National Cytometry Platform at the Luxembourg Institute of Health received funding by the European Regional Development Fund (F.E.D.E.R.) for the CyTOF instrument.

PY - 2018/4/5

Y1 - 2018/4/5

UR - http://www.scopus.com/inward/record.url?scp=85047642164&partnerID=8YFLogxK

UR - https://pubmed.ncbi.nlm.nih.gov/29439955

U2 - 10.1182/blood-2017-06-792267

DO - 10.1182/blood-2017-06-792267

M3 - Letter

C2 - 29439955

AN - SCOPUS:85047642164

SN - 0006-4971

VL - 131

SP - 1617

EP - 1621

JO - Blood

JF - Blood

IS - 14

ER -

Dual PD1/LAG3 immune checkpoint blockade limits tumor development in a murine model of chronic lymphocytic leukemia

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