Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

Frédérique Hauss, Jiawei Liu, Alessandro Michelucci, Djalil Coowar, Eleonora Morga, Paul Heuschling, Bang Luu*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.

Original languageEnglish
Pages (from-to)4218-4222
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number15
DOIs
Publication statusPublished - 1 Aug 2007
Externally publishedYes

Keywords

  • Microglia
  • Neural stem cells
  • Neurodegenerative diseases
  • Neuroinflammation
  • Resveratrol fatty alcohols

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