TY - JOUR
T1 - Dual bioactivity of resveratrol fatty alcohols
T2 - Differentiation of neural stem cells and modulation of neuroinflammation
AU - Hauss, Frédérique
AU - Liu, Jiawei
AU - Michelucci, Alessandro
AU - Coowar, Djalil
AU - Morga, Eleonora
AU - Heuschling, Paul
AU - Luu, Bang
N1 - Funding Information:
This work was supported by a PhD and Post-doctoral Fellowship Program from the Luxembourg Ministry of Culture, Higher Education and Research (F.H., A.M., and D.C.). Special thanks to Prof. N.S. Yang (Taipei) for critical reading of the manuscript.
PY - 2007/8/1
Y1 - 2007/8/1
N2 - The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.
AB - The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.
KW - Microglia
KW - Neural stem cells
KW - Neurodegenerative diseases
KW - Neuroinflammation
KW - Resveratrol fatty alcohols
UR - http://www.scopus.com/inward/record.url?scp=34447092157&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2007.05.037
DO - 10.1016/j.bmcl.2007.05.037
M3 - Article
C2 - 17560107
AN - SCOPUS:34447092157
SN - 0960-894X
VL - 17
SP - 4218
EP - 4222
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 15
ER -