Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

Frédérique Hauss; Jiawei Liu; Alessandro Michelucci; Djalil Coowar; Eleonora Morga; Paul Heuschling; Bang Luu

doi:10.1016/j.bmcl.2007.05.037

Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

Frédérique Hauss, Jiawei Liu, Alessandro Michelucci, Djalil Coowar, Eleonora Morga, Paul Heuschling, Bang Luu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.

Original language	English
Pages (from-to)	4218-4222
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2007.05.037
Publication status	Published - 1 Aug 2007
Externally published	Yes

Keywords

Microglia
Neural stem cells
Neurodegenerative diseases
Neuroinflammation
Resveratrol fatty alcohols

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10.1016/j.bmcl.2007.05.037

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title = "Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation",

abstract = "The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.",

keywords = "Microglia, Neural stem cells, Neurodegenerative diseases, Neuroinflammation, Resveratrol fatty alcohols",

author = "Fr{\'e}d{\'e}rique Hauss and Jiawei Liu and Alessandro Michelucci and Djalil Coowar and Eleonora Morga and Paul Heuschling and Bang Luu",

note = "Funding Information: This work was supported by a PhD and Post-doctoral Fellowship Program from the Luxembourg Ministry of Culture, Higher Education and Research (F.H., A.M., and D.C.). Special thanks to Prof. N.S. Yang (Taipei) for critical reading of the manuscript. ",

year = "2007",

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doi = "10.1016/j.bmcl.2007.05.037",

language = "English",

volume = "17",

pages = "4218--4222",

journal = "Bioorganic and Medicinal Chemistry Letters",

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publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - Dual bioactivity of resveratrol fatty alcohols

T2 - Differentiation of neural stem cells and modulation of neuroinflammation

AU - Hauss, Frédérique

AU - Liu, Jiawei

AU - Michelucci, Alessandro

AU - Coowar, Djalil

AU - Morga, Eleonora

AU - Heuschling, Paul

AU - Luu, Bang

N1 - Funding Information: This work was supported by a PhD and Post-doctoral Fellowship Program from the Luxembourg Ministry of Culture, Higher Education and Research (F.H., A.M., and D.C.). Special thanks to Prof. N.S. Yang (Taipei) for critical reading of the manuscript.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.

AB - The synthesis of resveratrol fatty alcohols (RFAs), a new class of small molecules presenting strong potential for the treatment of neurological diseases, is described. RFAs, hybrid compounds combining the resveratrol nucleus and ω-alkanol side chains, are able to modulate neuroinflammation and to induce differentiation of neural stem cells into mature neurons. Acting on neuroprotection and neuroregeneration, RFAs represent an innovative approach for the treatment or cure of neuropathies.

KW - Microglia

KW - Neural stem cells

KW - Neurodegenerative diseases

KW - Neuroinflammation

KW - Resveratrol fatty alcohols

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U2 - 10.1016/j.bmcl.2007.05.037

DO - 10.1016/j.bmcl.2007.05.037

M3 - Article

C2 - 17560107

AN - SCOPUS:34447092157

SN - 0960-894X

VL - 17

SP - 4218

EP - 4222

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Dual bioactivity of resveratrol fatty alcohols: Differentiation of neural stem cells and modulation of neuroinflammation

Abstract

Keywords

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