Drug-domain interaction networks in myocardial infarction

Haiying Wang, Huiru Zheng, Francisco Azuaje, Xing Ming Zhao

    Research output: Contribution to journalArticleResearchpeer-review

    2 Citations (Scopus)


    It has been well recognized that the pace of the development of new drugs and therapeutic interventions lags far behind biological knowledge discovery. Network-based approaches have emerged as a promising alternative to accelerate the discovery of new safe and effective drugs. Based on the integration of several biological resources including two recently published datasets i.e., Drug-target interactions in myocardial infarction (My-DTome) and drug-domain interaction network, this paper reports the association between drugs and protein domains in the context of myocardial infarction (MI). A MI drug-domain interaction network, My-DDome, was firstly constructed, followed by topological analysis and functional characterization of the network. The results show that My-DDome has a very clear modular structure, where drugs interacting with the same domain(s) within each module tend to have similar therapeutic effects. Moreover it has been found that drugs acting on blood and blood forming organs (ATC code B) and sensory organs (ATC code S) are significantly enriched in My-DDome $(p < 0.000001)$ , indicating that by incorporating protein domain information into My-DTome, more detailed insights into the interplay between drugs, their known targets, and seemingly unrelated proteins can be revealed.

    Original languageEnglish
    Article number6582675
    Pages (from-to)182-188
    Number of pages7
    JournalIEEE Transactions on Nanobioscience
    Issue number3
    Publication statusPublished - 2013


    • Drug-domain interactions
    • myocardial infarction
    • network-based approaches


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