Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target

Muhammad Zaeem Noman, Jerome Paggetti, Etienne Moussay, Guy Berchem, Bassam Janji*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition as a cutting-edge approach to fully exploit the anti-tumor properties of NK cells in a wide variety of cancer patients.

Original languageEnglish
Article numbere1452583
JournalOncoImmunology
Volume7
Issue number8
DOIs
Publication statusPublished - 3 Aug 2018

Keywords

  • Beclin1
  • CCL5 cytokine
  • Immune infiltration
  • autophagy
  • cancer immunotherapy
  • immunotherapy
  • melanoma
  • natural killer cells

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