Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target

Muhammad Zaeem Noman; Jerome Paggetti; Etienne Moussay; Guy Berchem; Bassam Janji

doi:10.1080/2162402X.2018.1452583

Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target

Muhammad Zaeem Noman, Jerome Paggetti, Etienne Moussay, Guy Berchem, Bassam Janji^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition as a cutting-edge approach to fully exploit the anti-tumor properties of NK cells in a wide variety of cancer patients.

Original language	English
Article number	e1452583
Journal	OncoImmunology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1080/2162402X.2018.1452583
Publication status	Published - 3 Aug 2018

Keywords

Beclin1
CCL5 cytokine
Immune infiltration
autophagy
cancer immunotherapy
immunotherapy
melanoma
natural killer cells

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10.1080/2162402X.2018.1452583

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title = "Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target",

abstract = "Natural Killer (NK) cell-based cancer immunotherapies were often disappointing in the clinic mostly due to insufficient NK cell infiltration into tumors. We found that targeting autophagy induced a massive infiltration of NK cells into melanoma tumors. These findings highlight autophagy inhibition as a cutting-edge approach to fully exploit the anti-tumor properties of NK cells in a wide variety of cancer patients.",

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AU - Janji, Bassam

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KW - Immune infiltration

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Driving Natural Killer cells toward the melanoma tumor battlefield: Autophagy as a valuable therapeutic target

Abstract

Keywords

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