TY - JOUR
T1 - Does the rs9939609 FTO gene polymorphism affect fat percentage?
T2 - A meta-analysis
AU - Gholamalizadeh, Maryam
AU - Mirzaei Dahka, Samaneh
AU - Vahid, Farhad
AU - Bourbour, Fatemeh
AU - Badeli, Mostafa
AU - JavadiKooshesh, Sepehr
AU - Mosavi Jarrahi, Seyed Alireza
AU - Akbari, Mohammad Esmail
AU - Azizi Tabesh, Ghasem
AU - Montazeri, Fatemeh
AU - Hassanpour, Ayemeh
AU - Doaei, Saeid
N1 - Funding Information:
This article is adapted from a research project approved by the Student Research Committee of Guilan University of Medical Sciences, Rasht, Iran (code 98050510). All colleagues in this university are warmly appreciated for their support and contribution.
Publisher Copyright:
© 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/6/23
Y1 - 2020/6/23
N2 - This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Studies that meet inclusion criteria were collected for the final analysis. There was significant differences in the level of BF% between different genotypes of FTO rs9939609 polymorphism, and the carriers of the A allele of FTO rs9939609 polymorphism had higher BF%. The association was significant between carriers of TT genotype compared to carriers of AA (p =.007) and AT genotypes (p =.04), but not between AT and AA genotypes. This study identified that the carriers of the A allele of FTO rs9939609 polymorphism have higher BF%.
AB - This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Studies that meet inclusion criteria were collected for the final analysis. There was significant differences in the level of BF% between different genotypes of FTO rs9939609 polymorphism, and the carriers of the A allele of FTO rs9939609 polymorphism had higher BF%. The association was significant between carriers of TT genotype compared to carriers of AA (p =.007) and AT genotypes (p =.04), but not between AT and AA genotypes. This study identified that the carriers of the A allele of FTO rs9939609 polymorphism have higher BF%.
KW - FTO
KW - The fat mass and obesity associated
KW - body fat
KW - polymorphism
UR - https://www.scopus.com/pages/publications/85087360655
U2 - 10.1080/13813455.2020.1773861
DO - 10.1080/13813455.2020.1773861
M3 - Review article
C2 - 32574121
AN - SCOPUS:85087360655
SN - 1381-3455
SP - 1421
EP - 1425
JO - Archives of Physiology and Biochemistry
JF - Archives of Physiology and Biochemistry
ER -