Does the rs9939609 FTO gene polymorphism affect fat percentage? A meta-analysis

Maryam Gholamalizadeh, Samaneh Mirzaei Dahka, Farhad Vahid, Fatemeh Bourbour, Mostafa Badeli, Sepehr JavadiKooshesh, Seyed Alireza Mosavi Jarrahi, Mohammad Esmail Akbari, Ghasem Azizi Tabesh, Fatemeh Montazeri, Ayemeh Hassanpour, Saeid Doaei*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

This meta-analysis aimed to investigate the association of the rs9939609 FTO gene polymorphism and body fat percentage (BF%). To the best of our knowledge, this study is the first meta-analysis to evaluate the relationship between FTO rs9939609 polymorphism and BF%. We searched PubMed, Web of science, Scopus and Embase to identify studies investigating the relations between the rs9939609 FTO gene polymorphism and BF%. Studies that meet inclusion criteria were collected for the final analysis. There was significant differences in the level of BF% between different genotypes of FTO rs9939609 polymorphism, and the carriers of the A allele of FTO rs9939609 polymorphism had higher BF%. The association was significant between carriers of TT genotype compared to carriers of AA (p =.007) and AT genotypes (p =.04), but not between AT and AA genotypes. This study identified that the carriers of the A allele of FTO rs9939609 polymorphism have higher BF%.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalArchives of Physiology and Biochemistry
DOIs
Publication statusE-pub ahead of print - 23 Jun 2020
Externally publishedYes

Keywords

  • FTO
  • The fat mass and obesity associated
  • body fat
  • polymorphism

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