TY - JOUR
T1 - Dietary intake of vitamin D and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition
AU - Abbas, Sascha
AU - Linseisen, Jakob
AU - Rohrmann, Sabine
AU - Chang-Claude, Jenny
AU - Peeters, Petra H.
AU - Engel, Pierre
AU - Brustad, Magritt
AU - Lund, Eiliv
AU - Skeie, Guri
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Francoise
AU - Fagherazzi, Guy
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Buijsse, Brian
AU - Adarakis, George
AU - Ouranos, Vassilis
AU - Trichopoulou, Antonia
AU - Masala, Giovanna
AU - Krogh, Vittorio
AU - Mattiello, Amalia
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Buckland, Genevieve
AU - Suárez, Marcial Vicente Argüelles
AU - Sánchez, Maria José
AU - Chirlaque, Maria Dolores
AU - Barricarte, Aurelio
AU - Amiano, Pilar
AU - Manjer, Jonas
AU - Wirfält, Elisabet
AU - Lenner, Per
AU - Sund, Malin
AU - Bueno-De-Mesquita, H. B.
AU - Van Duijnhoven, Fränzel J.B.
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Key, Timothy J.
AU - Fedirko, Veronika
AU - Romieu, Isabelle
AU - Gallo, Valentina
AU - Norat, Teresa
AU - Wark, Petra A.
AU - Riboli, Elio
N1 - Funding Information:
EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Deutsche Krebshilfe, Deutsches Krebsforschungszen-trum and Federal Ministry of Education and Research (Germany); Hellenic Health Foundation, Stavros Niarchos Foundation and Hellenic Ministry of Health and Social Solidarity (Greece); Italian Association for Research on Cancer (AIRC) and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); ERC-2009-AdG 232997 and Nordforsk, Nordic Center of Excellence programme on Food, Nutrition and Health. (Norway); Health Research Fund (FIS), Regional Governments of An-dalucía, Asturias, Basque Country, Murcia (no. 6236) and Navarra, ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Scientific Council and Regional Government of Skåne and Västerbotten (Sweden); Cancer Research UK, Medical Research Council (United Kingdom); The Catalan In-situte of Oncology and RTICC ‘Red Tematica de Investigacion Cooperativa en Cancer (R06/0020) (Spain).
PY - 2013
Y1 - 2013
N2 - Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
AB - Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre-and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87-1.32) and 1.02 (0.90-1.16) for pre-and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80-1.19) and 0.90 (0.79-1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre-and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
UR - http://www.scopus.com/inward/record.url?scp=84874582812&partnerID=8YFLogxK
U2 - 10.1080/01635581.2013.752018
DO - 10.1080/01635581.2013.752018
M3 - Article
C2 - 23441605
AN - SCOPUS:84874582812
SN - 0163-5581
VL - 65
SP - 178
EP - 187
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 2
ER -