TY - JOUR
T1 - Dietary inflammatory index (DII) is correlated with the incidence of non-alcoholic fatty liver disease (NAFLD)
T2 - Fasa PERSIAN cohort study
AU - Valibeygi, Adib
AU - Davoodi, Ali
AU - Dehghan, Azizallah
AU - Vahid, Farhad
AU - Hébert, James R.
AU - Farjam, Mojtaba
AU - Homayounfar, Reza
N1 - Funding Information:
We would like to thank Fasa University of Medical Sciences for providing support to this research and also the staff of the non-communicable diseases research center (NCDRC) at this university for their efforts towards the cohort’s data collection.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/7/11
Y1 - 2023/7/11
N2 - Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disease predisposing patients to life-threatening conditions, including cirrhosis. There is evidence that the incidence of NAFLD is related to the individuals’ dietary patterns; however, it is still remaining unknown whether the inflammatory potential of various foods/dietary patterns can directly predict a higher incidence of NAFLD. Methods: In this cross-sectional cohort study, we investigated the relationship between the inflammatory potential of various food items and the incidence/odds of NAFLD. We used data from Fasa PERSIAN Cohort Study comprising 10,035 individuals. To measure the inflammatory potential of diet, we used the dietary inflammatory index (DII®). Fatty liver index (FLI) was also calculated for each individual to identify the presence of NAFLD (cut-off = 60). Results: Our findings showed that higher DII is significantly associated with increased incidence/odds of NAFLD (OR = 1.254, 95% CI: 1.178—1.334). Additionally, we found out that higher age, female gender, diabetes mellitus, hypertriglyceridemia, hypercholesterolemia, and hypertension are other predictors of developing NAFLD. Conclusions: It can be concluded that consuming foods with a higher inflammatory potential is associated with a greater risk of developing NAFLD. Additionally, metabolic diseases, including dyslipidemia, diabetes mellitus, and hypertension, can also predict the incidence of NAFLD.
AB - Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver disease predisposing patients to life-threatening conditions, including cirrhosis. There is evidence that the incidence of NAFLD is related to the individuals’ dietary patterns; however, it is still remaining unknown whether the inflammatory potential of various foods/dietary patterns can directly predict a higher incidence of NAFLD. Methods: In this cross-sectional cohort study, we investigated the relationship between the inflammatory potential of various food items and the incidence/odds of NAFLD. We used data from Fasa PERSIAN Cohort Study comprising 10,035 individuals. To measure the inflammatory potential of diet, we used the dietary inflammatory index (DII®). Fatty liver index (FLI) was also calculated for each individual to identify the presence of NAFLD (cut-off = 60). Results: Our findings showed that higher DII is significantly associated with increased incidence/odds of NAFLD (OR = 1.254, 95% CI: 1.178—1.334). Additionally, we found out that higher age, female gender, diabetes mellitus, hypertriglyceridemia, hypercholesterolemia, and hypertension are other predictors of developing NAFLD. Conclusions: It can be concluded that consuming foods with a higher inflammatory potential is associated with a greater risk of developing NAFLD. Additionally, metabolic diseases, including dyslipidemia, diabetes mellitus, and hypertension, can also predict the incidence of NAFLD.
KW - Diet
KW - Dietary inflammatory index
KW - Fatty liver index
KW - Hypercholesterolemia
KW - Hypertriglyceridemia
KW - Non-alcoholic fatty liver disease
UR - http://www.scopus.com/inward/record.url?scp=85165194079&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/37434233
U2 - 10.1186/s40795-023-00738-5
DO - 10.1186/s40795-023-00738-5
M3 - Article
C2 - 37434233
SN - 2055-0928
VL - 9
JO - BMC Nutrition
JF - BMC Nutrition
IS - 1
M1 - 84
ER -