Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition

J. D. De Batlle; P. Ferrari; V. Chajes; J. Y. Park; N. Slimani; F. McKenzie; K. Overvad; N. Roswall; A. Tjønneland; M. C. Boutron-Ruault; F. Clavel-Chapelon; G. Fagherazzi; V. Katzke; R. Kaaks; M. M. Bergmann; A. Trichopoulou; P. Lagiou; D. Trichopoulos; D. Palli; S. Sieri; S. Panico; R. Tumino; P. Vineis; H. B. Bueno-De-mesquita; P. H. Peeters; A. Hjartåker; D. Engeset; E. Weiderpass; S. Sánchez; N. Travier; M. J. Sánchez; P. Amiano; M. D. Chirlaque; A. Barricarte Gurrea; K. T. Khaw; T. J. Key; K. E. Bradbury; U. Ericson; E. Sonestedt; B. Van Guelpen; J. Schneede; E. Riboli; I. Romieu

doi:10.1093/jnci/dju367

Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition

J. D. De Batlle^*, P. Ferrari, V. Chajes, J. Y. Park, N. Slimani, F. McKenzie, K. Overvad, N. Roswall, A. Tjønneland, M. C. Boutron-Ruault, F. Clavel-Chapelon, G. Fagherazzi, V. Katzke, R. Kaaks, M. M. Bergmann, A. Trichopoulou, P. Lagiou, D. Trichopoulos, D. Palli, S. SieriS. Panico, R. Tumino, P. Vineis, H. B. Bueno-De-mesquita, P. H. Peeters, A. Hjartåker, D. Engeset, E. Weiderpass, S. Sánchez, N. Travier, M. J. Sánchez, P. Amiano, M. D. Chirlaque, A. Barricarte Gurrea, K. T. Khaw, T. J. Key, K. E. Bradbury, U. Ericson, E. Sonestedt, B. Van Guelpen, J. Schneede, E. Riboli, I. Romieu

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

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Abstract

Background: There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A total of 367 993 women age 35 to 70 years were recruited in 10 European countries. During a median followup of 11.5 years, 11 575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. Results: A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HR_Q5-Q1] = 0.92, 95% CI = 0.83 to 1.01, P_trend =.037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HR_Q5-Q1 = 0.66, 95% CI = 0.45 to 0.96, P_trend =.042) and progesterone receptor-negative BC (HR_Q5-Q1 = 0.70, 95% CI = 0.51 to 0.97, P_trend =.021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (>12 alcoholic drinks/week) alcohol intake (HR_T3-T1 = 0.86, 95% CI = 0.75 to 0.98, P_interaction =.035). Conclusions: Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.

Original language	English
Article number	dju367
Journal	Journal of the National Cancer Institute
Volume	107
Issue number	1
DOIs	https://doi.org/10.1093/jnci/dju367
Publication status	Published - 1 Jan 2015
Externally published	Yes

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De Batlle, J. D., Ferrari, P., Chajes, V., Park, J. Y., Slimani, N., McKenzie, F., Overvad, K., Roswall, N., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, G., Katzke, V., Kaaks, R., Bergmann, M. M., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., ... Romieu, I. (2015). Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition. Journal of the National Cancer Institute, 107(1), Article dju367. https://doi.org/10.1093/jnci/dju367

@article{4a5752659b394c349307230ec59ff5ad,

title = "Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition",

abstract = "Background: There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A total of 367 993 women age 35 to 70 years were recruited in 10 European countries. During a median followup of 11.5 years, 11 575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. Results: A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, Ptrend =.037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, Ptrend =.042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, Ptrend =.021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (>12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, Pinteraction =.035). Conclusions: Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.",

author = "{De Batlle}, {J. D.} and P. Ferrari and V. Chajes and Park, {J. Y.} and N. Slimani and F. McKenzie and K. Overvad and N. Roswall and A. Tj{\o}nneland and Boutron-Ruault, {M. C.} and F. Clavel-Chapelon and G. Fagherazzi and V. Katzke and R. Kaaks and Bergmann, {M. M.} and A. Trichopoulou and P. Lagiou and D. Trichopoulos and D. Palli and S. Sieri and S. Panico and R. Tumino and P. Vineis and Bueno-De-mesquita, {H. B.} and Peeters, {P. H.} and A. Hjart{\aa}ker and D. Engeset and E. Weiderpass and S. S{\'a}nchez and N. Travier and S{\'a}nchez, {M. J.} and P. Amiano and Chirlaque, {M. D.} and Gurrea, {A. Barricarte} and Khaw, {K. T.} and Key, {T. J.} and Bradbury, {K. E.} and U. Ericson and E. Sonestedt and {Van Guelpen}, B. and J. Schneede and E. Riboli and I. Romieu",

note = "Publisher Copyright: {\textcopyright} The Author 2014. Published by Oxford University Press.",

year = "2015",

month = jan,

day = "1",

doi = "10.1093/jnci/dju367",

language = "English",

volume = "107",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "1",

}

De Batlle, JD, Ferrari, P, Chajes, V, Park, JY, Slimani, N, McKenzie, F, Overvad, K, Roswall, N, Tjønneland, A, Boutron-Ruault, MC, Clavel-Chapelon, F, Fagherazzi, G, Katzke, V, Kaaks, R, Bergmann, MM, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Panico, S, Tumino, R, Vineis, P, Bueno-De-mesquita, HB, Peeters, PH, Hjartåker, A, Engeset, D, Weiderpass, E, Sánchez, S, Travier, N, Sánchez, MJ, Amiano, P, Chirlaque, MD, Gurrea, AB, Khaw, KT, Key, TJ, Bradbury, KE, Ericson, U, Sonestedt, E, Van Guelpen, B, Schneede, J, Riboli, E & Romieu, I 2015, 'Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition', Journal of the National Cancer Institute, vol. 107, no. 1, dju367. https://doi.org/10.1093/jnci/dju367

TY - JOUR

T1 - Dietary folate intake and breast cancer risk

T2 - European prospective investigation into cancer and nutrition

AU - De Batlle, J. D.

AU - Ferrari, P.

AU - Chajes, V.

AU - Park, J. Y.

AU - Slimani, N.

AU - McKenzie, F.

AU - Overvad, K.

AU - Roswall, N.

AU - Tjønneland, A.

AU - Boutron-Ruault, M. C.

AU - Clavel-Chapelon, F.

AU - Fagherazzi, G.

AU - Katzke, V.

AU - Kaaks, R.

AU - Bergmann, M. M.

AU - Trichopoulou, A.

AU - Lagiou, P.

AU - Trichopoulos, D.

AU - Palli, D.

AU - Sieri, S.

AU - Panico, S.

AU - Tumino, R.

AU - Vineis, P.

AU - Bueno-De-mesquita, H. B.

AU - Peeters, P. H.

AU - Hjartåker, A.

AU - Engeset, D.

AU - Weiderpass, E.

AU - Sánchez, S.

AU - Travier, N.

AU - Sánchez, M. J.

AU - Amiano, P.

AU - Chirlaque, M. D.

AU - Gurrea, A. Barricarte

AU - Khaw, K. T.

AU - Key, T. J.

AU - Bradbury, K. E.

AU - Ericson, U.

AU - Sonestedt, E.

AU - Van Guelpen, B.

AU - Schneede, J.

AU - Riboli, E.

AU - Romieu, I.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A total of 367 993 women age 35 to 70 years were recruited in 10 European countries. During a median followup of 11.5 years, 11 575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. Results: A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, Ptrend =.037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, Ptrend =.042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, Ptrend =.021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (>12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, Pinteraction =.035). Conclusions: Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.

AB - Background: There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A total of 367 993 women age 35 to 70 years were recruited in 10 European countries. During a median followup of 11.5 years, 11 575 women with BC were identified. Dietary folate intake was estimated from country-specific dietary questionnaires. Cox proportional hazards regression models were used to quantify the association between dietary variables and BC risk. BC tumors were classified by receptor status. Subgroup analyses were performed by menopausal status and alcohol intake. Intake of other B vitamins was considered. All statistical tests were two-sided. Results: A borderline inverse association was observed between dietary folate and BC risk (hazard ratio comparing top vs bottom quintile [HRQ5-Q1] = 0.92, 95% CI = 0.83 to 1.01, Ptrend =.037). In premenopausal women, we observed a statistically significant trend towards lower risk in estrogen receptor-negative BC (HRQ5-Q1 = 0.66, 95% CI = 0.45 to 0.96, Ptrend =.042) and progesterone receptor-negative BC (HRQ5-Q1 = 0.70, 95% CI = 0.51 to 0.97, Ptrend =.021). No associations were found in postmenopausal women. A 14% reduction in BC risk was observed when comparing the highest with the lowest dietary folate tertiles in women having a high (>12 alcoholic drinks/week) alcohol intake (HRT3-T1 = 0.86, 95% CI = 0.75 to 0.98, Pinteraction =.035). Conclusions: Higher dietary folate intake may be associated with a lower risk of sex hormone receptor-negative BC in premenopausal women.

UR - http://www.scopus.com/inward/record.url?scp=84923898805&partnerID=8YFLogxK

U2 - 10.1093/jnci/dju367

DO - 10.1093/jnci/dju367

M3 - Article

C2 - 25505228

AN - SCOPUS:84923898805

SN - 0027-8874

VL - 107

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 1

M1 - dju367

ER -

Dietary folate intake and breast cancer risk: European prospective investigation into cancer and nutrition

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