Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

Melissa A. Merritt; Elio Riboli; Elisabete Weiderpass; Konstantinos K. Tsilidis; Kim Overvad; Anne Tjønneland; Louise Hansen; Laure Dossus; Guy Fagherazzi; Laura Baglietto; Renée T. Fortner; Jennifer Ose; Annika Steffen; Heiner Boeing; Antonia Trichopoulou; Dimitrios Trichopoulos; Pagona Lagiou; Giovanna Masala; Sabina Sieri; Amalia Mattiello; Rosario Tumino; Carlotta Sacerdote; H. B(as) Bueno-de-Mesquita; N. Charlotte Onland-Moret; Petra H. Peeters; Anette Hjartåker; Inger Torhild Gram; J. Ramón Quirós; Mireia Obón-Santacana; Esther Molina-Montes; José María Huerta Castaño; Eva Ardanaz; Saioa Chamosa; Emily Sonestedt; Annika Idahl; Eva Lundin; Kay Tee Khaw; Nicholas Wareham; Ruth C. Travis; Sabina Rinaldi; Isabelle Romieu; Veronique Chajes; Marc J. Gunter

doi:10.1016/j.canep.2014.07.011

Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

Melissa A. Merritt^*, Elio Riboli, Elisabete Weiderpass, Konstantinos K. Tsilidis, Kim Overvad, Anne Tjønneland, Louise Hansen, Laure Dossus, Guy Fagherazzi, Laura Baglietto, Renée T. Fortner, Jennifer Ose, Annika Steffen, Heiner Boeing, Antonia Trichopoulou, Dimitrios Trichopoulos, Pagona Lagiou, Giovanna Masala, Sabina Sieri, Amalia MattielloRosario Tumino, Carlotta Sacerdote, H. B(as) Bueno-de-Mesquita, N. Charlotte Onland-Moret, Petra H. Peeters, Anette Hjartåker, Inger Torhild Gram, J. Ramón Quirós, Mireia Obón-Santacana, Esther Molina-Montes, José María Huerta Castaño, Eva Ardanaz, Saioa Chamosa, Emily Sonestedt, Annika Idahl, Eva Lundin, Kay Tee Khaw, Nicholas Wareham, Ruth C. Travis, Sabina Rinaldi, Isabelle Romieu, Veronique Chajes, Marc J. Gunter

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

18 Citations (Scopus)

Abstract

There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, P_trend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.

Original language	English
Pages (from-to)	528-537
Number of pages	10
Journal	Cancer Epidemiology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1016/j.canep.2014.07.011
Publication status	Published - 1 Oct 2014
Externally published	Yes

Keywords

Dietary fats
Ovarian cancer
Serous neoplasms
Unsaturated dietary fats

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10.1016/j.canep.2014.07.011

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Merritt, M. A., Riboli, E., Weiderpass, E., Tsilidis, K. K., Overvad, K., Tjønneland, A., Hansen, L., Dossus, L., Fagherazzi, G., Baglietto, L., Fortner, R. T., Ose, J., Steffen, A., Boeing, H., Trichopoulou, A., Trichopoulos, D., Lagiou, P., Masala, G., Sieri, S., ... Gunter, M. J. (2014). Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology, 38(5), 528-537. https://doi.org/10.1016/j.canep.2014.07.011

@article{65bc6bb1488548bda089aee8fac753ee,

title = "Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition",

abstract = "There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.",

keywords = "Dietary fats, Ovarian cancer, Serous neoplasms, Unsaturated dietary fats",

author = "Merritt, {Melissa A.} and Elio Riboli and Elisabete Weiderpass and Tsilidis, {Konstantinos K.} and Kim Overvad and Anne Tj{\o}nneland and Louise Hansen and Laure Dossus and Guy Fagherazzi and Laura Baglietto and Fortner, {Ren{\'e}e T.} and Jennifer Ose and Annika Steffen and Heiner Boeing and Antonia Trichopoulou and Dimitrios Trichopoulos and Pagona Lagiou and Giovanna Masala and Sabina Sieri and Amalia Mattiello and Rosario Tumino and Carlotta Sacerdote and Bueno-de-Mesquita, {H. B(as)} and Onland-Moret, {N. Charlotte} and Peeters, {Petra H.} and Anette Hjart{\aa}ker and Gram, {Inger Torhild} and Quir{\'o}s, {J. Ram{\'o}n} and Mireia Ob{\'o}n-Santacana and Esther Molina-Montes and {Huerta Casta{\~n}o}, {Jos{\'e} Mar{\'i}a} and Eva Ardanaz and Saioa Chamosa and Emily Sonestedt and Annika Idahl and Eva Lundin and Khaw, {Kay Tee} and Nicholas Wareham and Travis, {Ruth C.} and Sabina Rinaldi and Isabelle Romieu and Veronique Chajes and Gunter, {Marc J.}",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Ltd.",

year = "2014",

month = oct,

day = "1",

doi = "10.1016/j.canep.2014.07.011",

language = "English",

volume = "38",

pages = "528--537",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier BV",

number = "5",

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Merritt, MA, Riboli, E, Weiderpass, E, Tsilidis, KK, Overvad, K, Tjønneland, A, Hansen, L, Dossus, L, Fagherazzi, G, Baglietto, L, Fortner, RT, Ose, J, Steffen, A, Boeing, H, Trichopoulou, A, Trichopoulos, D, Lagiou, P, Masala, G, Sieri, S, Mattiello, A, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, HB, Onland-Moret, NC, Peeters, PH, Hjartåker, A, Gram, IT, Quirós, JR, Obón-Santacana, M, Molina-Montes, E, Huerta Castaño, JM, Ardanaz, E, Chamosa, S, Sonestedt, E, Idahl, A, Lundin, E, Khaw, KT, Wareham, N, Travis, RC, Rinaldi, S, Romieu, I, Chajes, V & Gunter, MJ 2014, 'Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition', Cancer Epidemiology, vol. 38, no. 5, pp. 528-537. https://doi.org/10.1016/j.canep.2014.07.011

TY - JOUR

T1 - Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

AU - Merritt, Melissa A.

AU - Riboli, Elio

AU - Weiderpass, Elisabete

AU - Tsilidis, Konstantinos K.

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Hansen, Louise

AU - Dossus, Laure

AU - Fagherazzi, Guy

AU - Baglietto, Laura

AU - Fortner, Renée T.

AU - Ose, Jennifer

AU - Steffen, Annika

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Lagiou, Pagona

AU - Masala, Giovanna

AU - Sieri, Sabina

AU - Mattiello, Amalia

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Bueno-de-Mesquita, H. B(as)

AU - Onland-Moret, N. Charlotte

AU - Peeters, Petra H.

AU - Hjartåker, Anette

AU - Gram, Inger Torhild

AU - Quirós, J. Ramón

AU - Obón-Santacana, Mireia

AU - Molina-Montes, Esther

AU - Huerta Castaño, José María

AU - Ardanaz, Eva

AU - Chamosa, Saioa

AU - Sonestedt, Emily

AU - Idahl, Annika

AU - Lundin, Eva

AU - Khaw, Kay Tee

AU - Wareham, Nicholas

AU - Travis, Ruth C.

AU - Rinaldi, Sabina

AU - Romieu, Isabelle

AU - Chajes, Veronique

AU - Gunter, Marc J.

PY - 2014/10/1

Y1 - 2014/10/1

N2 - There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.

AB - There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.

KW - Dietary fats

KW - Ovarian cancer

KW - Serous neoplasms

KW - Unsaturated dietary fats

UR - http://www.scopus.com/inward/record.url?scp=84908075396&partnerID=8YFLogxK

U2 - 10.1016/j.canep.2014.07.011

DO - 10.1016/j.canep.2014.07.011

M3 - Article

C2 - 25155210

AN - SCOPUS:84908075396

SN - 1877-7821

VL - 38

SP - 528

EP - 537

JO - Cancer Epidemiology

JF - Cancer Epidemiology

IS - 5

ER -

Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition

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Keywords

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