Dietary fat intake and development of specific breast cancer subtypes

Sabina Sieri; Paolo Chiodini; Claudia Agnoli; Valeria Pala; Franco Berrino; Antonia Trichopoulou; Vassiliki Benetou; Effie Vasilopoulou; María José Sánchez; Maria Dolores Chirlaque; Pilar Amiano; J. Ramón Quirós; Eva Ardanaz; Genevieve Buckland; Giovanna Masala; Salvatore Panico; Sara Grioni; Carlotta Sacerdote; Rosario Tumino; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Guy Fagherazzi; Petra H.M. Peeters; Carla H. Van Gils; H. Bas Bueno-De-Mesquita; Henk J. Van Kranen; Timothy J. Key; Ruth C. Travis; Kay Tee Khaw; Nicholas J. Wareham; Rudolf Kaaks; Annekatrin Lukanova; Heiner Boeing; Madlen Schütze; Emily Sonestedt; Elisabeth Wirfält; Malin Sund; Anne Andersson; Veronique Chajes; Sabina Rinaldi; Isabelle Romieu; Elisabete Weiderpass; Guri Skeie; Engeset Dagrun; Anne Tjonneland; Jytte Halkjær; Kim Overvard; Melissa A. Merritt; David Cox; Elio Riboli; Vittorio Krogh

doi:10.1093/jnci/dju068

Dietary fat intake and development of specific breast cancer subtypes

Sabina Sieri^*, Paolo Chiodini, Claudia Agnoli, Valeria Pala, Franco Berrino, Antonia Trichopoulou, Vassiliki Benetou, Effie Vasilopoulou, María José Sánchez, Maria Dolores Chirlaque, Pilar Amiano, J. Ramón Quirós, Eva Ardanaz, Genevieve Buckland, Giovanna Masala, Salvatore Panico, Sara Grioni, Carlotta Sacerdote, Rosario Tumino, Marie Christine Boutron-RuaultFrançoise Clavel-Chapelon, Guy Fagherazzi, Petra H.M. Peeters, Carla H. Van Gils, H. Bas Bueno-De-Mesquita, Henk J. Van Kranen, Timothy J. Key, Ruth C. Travis, Kay Tee Khaw, Nicholas J. Wareham, Rudolf Kaaks, Annekatrin Lukanova, Heiner Boeing, Madlen Schütze, Emily Sonestedt, Elisabeth Wirfält, Malin Sund, Anne Andersson, Veronique Chajes, Sabina Rinaldi, Isabelle Romieu, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Anne Tjonneland, Jytte Halkjær, Kim Overvard, Melissa A. Merritt, David Cox, Elio Riboli, Vittorio Krogh

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

90 Citations (Scopus)

Abstract

We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER ⁺PR⁺ disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER^-PR^- disease. High saturated fat was statistically significantly associated with greater risk of HER2^- disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

Original language	English
Journal	Journal of the National Cancer Institute
Volume	106
Issue number	5
DOIs	https://doi.org/10.1093/jnci/dju068
Publication status	Published - 14 May 2014
Externally published	Yes

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Sieri, S., Chiodini, P., Agnoli, C., Pala, V., Berrino, F., Trichopoulou, A., Benetou, V., Vasilopoulou, E., Sánchez, M. J., Chirlaque, M. D., Amiano, P., Quirós, J. R., Ardanaz, E., Buckland, G., Masala, G., Panico, S., Grioni, S., Sacerdote, C., Tumino, R., ... Krogh, V. (2014). Dietary fat intake and development of specific breast cancer subtypes. Journal of the National Cancer Institute, 106(5). https://doi.org/10.1093/jnci/dju068

@article{4b77193b44a24969af7f37d964d9c53d,

title = "Dietary fat intake and development of specific breast cancer subtypes",

abstract = "We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER +PR+ disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER-PR- disease. High saturated fat was statistically significantly associated with greater risk of HER2- disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.",

author = "Sabina Sieri and Paolo Chiodini and Claudia Agnoli and Valeria Pala and Franco Berrino and Antonia Trichopoulou and Vassiliki Benetou and Effie Vasilopoulou and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Chirlaque, {Maria Dolores} and Pilar Amiano and Quir{\'o}s, {J. Ram{\'o}n} and Eva Ardanaz and Genevieve Buckland and Giovanna Masala and Salvatore Panico and Sara Grioni and Carlotta Sacerdote and Rosario Tumino and Boutron-Ruault, {Marie Christine} and Fran{\c c}oise Clavel-Chapelon and Guy Fagherazzi and Peeters, {Petra H.M.} and {Van Gils}, {Carla H.} and Bueno-De-Mesquita, {H. Bas} and {Van Kranen}, {Henk J.} and Key, {Timothy J.} and Travis, {Ruth C.} and Khaw, {Kay Tee} and Wareham, {Nicholas J.} and Rudolf Kaaks and Annekatrin Lukanova and Heiner Boeing and Madlen Sch{\"u}tze and Emily Sonestedt and Elisabeth Wirf{\"a}lt and Malin Sund and Anne Andersson and Veronique Chajes and Sabina Rinaldi and Isabelle Romieu and Elisabete Weiderpass and Guri Skeie and Engeset Dagrun and Anne Tjonneland and Jytte Halkj{\ae}r and Kim Overvard and Merritt, {Melissa A.} and David Cox and Elio Riboli and Vittorio Krogh",

year = "2014",

month = may,

day = "14",

doi = "10.1093/jnci/dju068",

language = "English",

volume = "106",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "5",

}

Sieri, S, Chiodini, P, Agnoli, C, Pala, V, Berrino, F, Trichopoulou, A, Benetou, V, Vasilopoulou, E, Sánchez, MJ, Chirlaque, MD, Amiano, P, Quirós, JR, Ardanaz, E, Buckland, G, Masala, G, Panico, S, Grioni, S, Sacerdote, C, Tumino, R, Boutron-Ruault, MC, Clavel-Chapelon, F, Fagherazzi, G, Peeters, PHM, Van Gils, CH, Bueno-De-Mesquita, HB, Van Kranen, HJ, Key, TJ, Travis, RC, Khaw, KT, Wareham, NJ, Kaaks, R, Lukanova, A, Boeing, H, Schütze, M, Sonestedt, E, Wirfält, E, Sund, M, Andersson, A, Chajes, V, Rinaldi, S, Romieu, I, Weiderpass, E, Skeie, G, Dagrun, E, Tjonneland, A, Halkjær, J, Overvard, K, Merritt, MA, Cox, D, Riboli, E & Krogh, V 2014, 'Dietary fat intake and development of specific breast cancer subtypes', Journal of the National Cancer Institute, vol. 106, no. 5. https://doi.org/10.1093/jnci/dju068

TY - JOUR

T1 - Dietary fat intake and development of specific breast cancer subtypes

AU - Sieri, Sabina

AU - Chiodini, Paolo

AU - Agnoli, Claudia

AU - Pala, Valeria

AU - Berrino, Franco

AU - Trichopoulou, Antonia

AU - Benetou, Vassiliki

AU - Vasilopoulou, Effie

AU - Sánchez, María José

AU - Chirlaque, Maria Dolores

AU - Amiano, Pilar

AU - Quirós, J. Ramón

AU - Ardanaz, Eva

AU - Buckland, Genevieve

AU - Masala, Giovanna

AU - Panico, Salvatore

AU - Grioni, Sara

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Boutron-Ruault, Marie Christine

AU - Clavel-Chapelon, Françoise

AU - Fagherazzi, Guy

AU - Peeters, Petra H.M.

AU - Van Gils, Carla H.

AU - Bueno-De-Mesquita, H. Bas

AU - Van Kranen, Henk J.

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Kaaks, Rudolf

AU - Lukanova, Annekatrin

AU - Boeing, Heiner

AU - Schütze, Madlen

AU - Sonestedt, Emily

AU - Wirfält, Elisabeth

AU - Sund, Malin

AU - Andersson, Anne

AU - Chajes, Veronique

AU - Rinaldi, Sabina

AU - Romieu, Isabelle

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Dagrun, Engeset

AU - Tjonneland, Anne

AU - Halkjær, Jytte

AU - Overvard, Kim

AU - Merritt, Melissa A.

AU - Cox, David

AU - Riboli, Elio

AU - Krogh, Vittorio

PY - 2014/5/14

Y1 - 2014/5/14

N2 - We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER +PR+ disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER-PR- disease. High saturated fat was statistically significantly associated with greater risk of HER2- disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

AB - We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER +PR+ disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER-PR- disease. High saturated fat was statistically significantly associated with greater risk of HER2- disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

UR - http://www.scopus.com/inward/record.url?scp=84905196278&partnerID=8YFLogxK

U2 - 10.1093/jnci/dju068

DO - 10.1093/jnci/dju068

M3 - Article

C2 - 24718872

AN - SCOPUS:84905196278

SN - 0027-8874

VL - 106

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 5

ER -

Dietary fat intake and development of specific breast cancer subtypes

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