Dietary fat intake and development of specific breast cancer subtypes

Sabina Sieri*, Paolo Chiodini, Claudia Agnoli, Valeria Pala, Franco Berrino, Antonia Trichopoulou, Vassiliki Benetou, Effie Vasilopoulou, María José Sánchez, Maria Dolores Chirlaque, Pilar Amiano, J. Ramón Quirós, Eva Ardanaz, Genevieve Buckland, Giovanna Masala, Salvatore Panico, Sara Grioni, Carlotta Sacerdote, Rosario Tumino, Marie Christine Boutron-RuaultFrançoise Clavel-Chapelon, Guy Fagherazzi, Petra H.M. Peeters, Carla H. Van Gils, H. Bas Bueno-De-Mesquita, Henk J. Van Kranen, Timothy J. Key, Ruth C. Travis, Kay Tee Khaw, Nicholas J. Wareham, Rudolf Kaaks, Annekatrin Lukanova, Heiner Boeing, Madlen Schütze, Emily Sonestedt, Elisabeth Wirfält, Malin Sund, Anne Andersson, Veronique Chajes, Sabina Rinaldi, Isabelle Romieu, Elisabete Weiderpass, Guri Skeie, Engeset Dagrun, Anne Tjonneland, Jytte Halkjær, Kim Overvard, Melissa A. Merritt, David Cox, Elio Riboli, Vittorio Krogh

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)


We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER +PR+ disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER-PR- disease. High saturated fat was statistically significantly associated with greater risk of HER2- disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.

Original languageEnglish
JournalJournal of the National Cancer Institute
Issue number5
Publication statusPublished - 14 May 2014
Externally publishedYes


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