Dietary copper/zinc ratio and type 2 diabetes risk in women: The E3N cohort study

Nasser Laouali; Conor James Macdonald; Sanam Shah; Douae El Fatouhi; Francesca Romana Mancini; Guy Fagherazzi; Marie Christine Boutron-Ruault

doi:10.3390/nu13082502

Dietary copper/zinc ratio and type 2 diabetes risk in women: The E3N cohort study

Nasser Laouali, Conor James Macdonald, Sanam Shah, Douae El Fatouhi, Francesca Romana Mancini, Guy Fagherazzi, Marie Christine Boutron-Ruault^*

^*Corresponding author for this work

Department of Precision Health

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

The serum copper (Cu) to zinc (Zn) ratio could be an important determinant of Type 2 diabetes (T2D) risk, but prospective epidemiological data are scarce. We aimed to investigate the association between T2D incidence and the dietary Cu/Zn ratio. A total of 70,991 women from the E3N cohort study were followed for 20 years. The intakes of copper and zinc were estimated at baseline using a validated food frequency questionnaire. We identified and validated 3292 incident T2D cases. Spline analysis showed that a Cu/Zn ratio < 0.55 was associated with a lower risk of T2D. Subgroup analyses comparing women in the highest versus the lowest quintile of Cu/Zn ratio showed the same pattern of association for obese women and those with zinc intake ≥8 mg/day. However, for women with zinc intake <8 mg/day, higher Cu/Zn ratio appeared to be associated with higher T2D risk. Our findings suggest that a lower dietary Cu/Zn ratio is associated with a lower T2D risk, especially among obese women and women with zinc intake >8 mg/day. Further studies are warranted to validate our results.

Original language	English
Article number	2502
Journal	Nutrients
Volume	13
Issue number	8
DOIs	https://doi.org/10.3390/nu13082502
Publication status	Published - 22 Jul 2021

Keywords

Copper
Diet
Epidemiology
Obesity
Observational study
Type 2 diabetes
Women
Zinc

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title = "Dietary copper/zinc ratio and type 2 diabetes risk in women: The E3N cohort study",

abstract = "The serum copper (Cu) to zinc (Zn) ratio could be an important determinant of Type 2 diabetes (T2D) risk, but prospective epidemiological data are scarce. We aimed to investigate the association between T2D incidence and the dietary Cu/Zn ratio. A total of 70,991 women from the E3N cohort study were followed for 20 years. The intakes of copper and zinc were estimated at baseline using a validated food frequency questionnaire. We identified and validated 3292 incident T2D cases. Spline analysis showed that a Cu/Zn ratio < 0.55 was associated with a lower risk of T2D. Subgroup analyses comparing women in the highest versus the lowest quintile of Cu/Zn ratio showed the same pattern of association for obese women and those with zinc intake ≥8 mg/day. However, for women with zinc intake <8 mg/day, higher Cu/Zn ratio appeared to be associated with higher T2D risk. Our findings suggest that a lower dietary Cu/Zn ratio is associated with a lower T2D risk, especially among obese women and women with zinc intake >8 mg/day. Further studies are warranted to validate our results.",

keywords = "Copper, Diet, Epidemiology, Obesity, Observational study, Type 2 diabetes, Women, Zinc",

author = "Nasser Laouali and Macdonald, {Conor James} and Sanam Shah and {El Fatouhi}, Douae and Mancini, {Francesca Romana} and Guy Fagherazzi and Boutron-Ruault, {Marie Christine}",

note = "Funding Information: This work was supported by a grant for the Nutriperso Project (IDEX Paris Saclay). This research was carried out using data from Inserm?s E3N cohort with the support of the MGEN, the Institut GUSTAVE ROUSSY and the Ligue contre le Cancer for the constitution and maintenance of the E3N cohort. This work has also benefited from state aid managed by the National Research Agency under the program ?Investissement d?avenir? under the reference ANR-10-COHO-0006 as well as a subsidy from the ?Minist?re de l?enseignement sup?rieur, de la recherche et de l?innovation? for public service charges under the reference n 2102 918823. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = jul,

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doi = "10.3390/nu13082502",

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volume = "13",

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T1 - Dietary copper/zinc ratio and type 2 diabetes risk in women

T2 - The E3N cohort study

AU - Laouali, Nasser

AU - Macdonald, Conor James

AU - Shah, Sanam

AU - El Fatouhi, Douae

AU - Mancini, Francesca Romana

AU - Fagherazzi, Guy

AU - Boutron-Ruault, Marie Christine

N1 - Funding Information: This work was supported by a grant for the Nutriperso Project (IDEX Paris Saclay). This research was carried out using data from Inserm?s E3N cohort with the support of the MGEN, the Institut GUSTAVE ROUSSY and the Ligue contre le Cancer for the constitution and maintenance of the E3N cohort. This work has also benefited from state aid managed by the National Research Agency under the program ?Investissement d?avenir? under the reference ANR-10-COHO-0006 as well as a subsidy from the ?Minist?re de l?enseignement sup?rieur, de la recherche et de l?innovation? for public service charges under the reference n 2102 918823. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/7/22

Y1 - 2021/7/22

N2 - The serum copper (Cu) to zinc (Zn) ratio could be an important determinant of Type 2 diabetes (T2D) risk, but prospective epidemiological data are scarce. We aimed to investigate the association between T2D incidence and the dietary Cu/Zn ratio. A total of 70,991 women from the E3N cohort study were followed for 20 years. The intakes of copper and zinc were estimated at baseline using a validated food frequency questionnaire. We identified and validated 3292 incident T2D cases. Spline analysis showed that a Cu/Zn ratio < 0.55 was associated with a lower risk of T2D. Subgroup analyses comparing women in the highest versus the lowest quintile of Cu/Zn ratio showed the same pattern of association for obese women and those with zinc intake ≥8 mg/day. However, for women with zinc intake <8 mg/day, higher Cu/Zn ratio appeared to be associated with higher T2D risk. Our findings suggest that a lower dietary Cu/Zn ratio is associated with a lower T2D risk, especially among obese women and women with zinc intake >8 mg/day. Further studies are warranted to validate our results.

AB - The serum copper (Cu) to zinc (Zn) ratio could be an important determinant of Type 2 diabetes (T2D) risk, but prospective epidemiological data are scarce. We aimed to investigate the association between T2D incidence and the dietary Cu/Zn ratio. A total of 70,991 women from the E3N cohort study were followed for 20 years. The intakes of copper and zinc were estimated at baseline using a validated food frequency questionnaire. We identified and validated 3292 incident T2D cases. Spline analysis showed that a Cu/Zn ratio < 0.55 was associated with a lower risk of T2D. Subgroup analyses comparing women in the highest versus the lowest quintile of Cu/Zn ratio showed the same pattern of association for obese women and those with zinc intake ≥8 mg/day. However, for women with zinc intake <8 mg/day, higher Cu/Zn ratio appeared to be associated with higher T2D risk. Our findings suggest that a lower dietary Cu/Zn ratio is associated with a lower T2D risk, especially among obese women and women with zinc intake >8 mg/day. Further studies are warranted to validate our results.

KW - Copper

KW - Diet

KW - Epidemiology

KW - Obesity

KW - Observational study

KW - Type 2 diabetes

KW - Women

KW - Zinc

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UR - https://www.ncbi.nlm.nih.gov/pubmed/34444662

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DO - 10.3390/nu13082502

M3 - Article

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AN - SCOPUS:85110620052

SN - 2072-6643

VL - 13

JO - Nutrients

JF - Nutrients

IS - 8

M1 - 2502

ER -

Dietary copper/zinc ratio and type 2 diabetes risk in women: The E3N cohort study

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