Dibenzofurans from the marine sponge-derived ascomycete Super1F1-09

Mostafa E. Rateb, Wael E. Houssen, Nathalie M. Legrave, Carol Clements, Marcel Jaspars, Rainer Ebel*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Three dibenzofurans hitherto undescribed from nature and one known butyrolactone were isolated from the extract of the ascomycete Super1F1-09 isolated from the Fijian marine sponge Acanthella cavernosa. The isolated compounds were identified as 3,9-dimethyldibenzo[b,d]furan-1,7-diol (1), 3-(hydroxymethyl)-9-methyldibenzo[b,d]furan-1,7-diol (2), 1,7-dihydroxy-9- methyldibenzo[b,d]furan-3-carboxylic acid (3), and the known butyrolactone I (4) using different NMR spectroscopic techniques and accurate mass spectrometric analysis. 1 was synthesized together with structurally related dibenzofurans 6-8. 1 and 4 had moderate antibacterial activity toward Mycobacterium marinum and Staphylococcus aureus, whereas 2 and 3 proved inactive. In addition, all compounds had moderate inhibitory properties against epidermal growth factor receptor tyrosine kinase.

Original languageEnglish
Pages (from-to)499-506
Number of pages8
JournalBotanica Marina
Volume53
Issue number6
DOIs
Publication statusPublished - 1 Dec 2010
Externally publishedYes

Keywords

  • Acanthella cavernosa
  • antibacterial activity
  • ascomycete
  • dibenzofurans
  • sponge-derived fungal metabolites
  • tyrosine kinase inhibition

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