Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Yuanzhen Su; Guanyu Jin; Huicong Zhou; Zhaofan Yang; Lanqing Wang; Zi Mei; Qionghua Jin; Shixian Lv; Xuesi Chen

doi:10.1515/mr-2022-0048

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Yuanzhen Su, Guanyu Jin, Huicong Zhou, Zhaofan Yang, Lanqing Wang, Zi Mei, Qionghua Jin, Shixian Lv^*, Xuesi Chen^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

Original language	English
Pages (from-to)	4-30
Number of pages	27
Journal	Medical Review
Volume	3
Issue number	1
DOIs	https://doi.org/10.1515/mr-2022-0048
Publication status	Published - 1 Feb 2023
Externally published	Yes

Keywords

cancer therapy
polymeric nanomedicines
stimuli responsive
tumor microenvironment

Access to Document

10.1515/mr-2022-0048

Cite this

@article{65ecb80788bb4b01b3199fc8df488c86,

title = "Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy",

abstract = "The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.",

keywords = "cancer therapy, polymeric nanomedicines, stimuli responsive, tumor microenvironment",

author = "Yuanzhen Su and Guanyu Jin and Huicong Zhou and Zhaofan Yang and Lanqing Wang and Zi Mei and Qionghua Jin and Shixian Lv and Xuesi Chen",

note = "Publisher Copyright: {\textcopyright} 2023 the author(s), published by De Gruyter, Berlin/Boston.",

year = "2023",

month = feb,

day = "1",

doi = "10.1515/mr-2022-0048",

language = "English",

volume = "3",

pages = "4--30",

journal = "Medical Review",

issn = "2749-9642",

publisher = "Walter de Gruyter GmbH",

number = "1",

}

TY - JOUR

T1 - Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

AU - Su, Yuanzhen

AU - Jin, Guanyu

AU - Zhou, Huicong

AU - Yang, Zhaofan

AU - Wang, Lanqing

AU - Mei, Zi

AU - Jin, Qionghua

AU - Lv, Shixian

AU - Chen, Xuesi

PY - 2023/2/1

Y1 - 2023/2/1

N2 - The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

AB - The complexity of the tumor microenvironment (TME) severely hinders the therapeutic effects of various cancer treatment modalities. The TME differs from normal tissues owing to the presence of hypoxia, low pH, and immune-suppressive characteristics. Modulation of the TME to reverse tumor growth equilibrium is considered an effective way to treat tumors. Recently, polymeric nanomedicines have been widely used in cancer therapy, because their synthesis can be controlled and they are highly modifiable, and have demonstrated great potential to remodel the TME. In this review, we outline the application of various stimuli responsive polymeric nanomedicines to modulate the TME, aiming to provide insights for the design of the next generation of polymeric nanomedicines and promote the development of polymeric nanomedicines for cancer therapy.

KW - cancer therapy

KW - polymeric nanomedicines

KW - stimuli responsive

KW - tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85154016276&partnerID=8YFLogxK

U2 - 10.1515/mr-2022-0048

DO - 10.1515/mr-2022-0048

M3 - Review article

AN - SCOPUS:85154016276

SN - 2749-9642

VL - 3

SP - 4

EP - 30

JO - Medical Review

JF - Medical Review

IS - 1

ER -

Development of stimuli responsive polymeric nanomedicines modulating tumor microenvironment for improved cancer therapy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this