Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI

Craig E. Stanley; Kimberly Fabrizio; Bridget A. McMahon; Auldyn Matthews-McGee; Cailey Fitzgerald; Zeina Singh; Nichole H. Rigby; John Michael Talarico; Ethan G. Brown; Monica Korell; Maggie McGuire Kuhl; Christina Destro; Nicola Pavese; Alicia Garrido; Brit Mollenhauer; Sohini Chowdhury; Kenneth Marek; Caroline M. Tanner; Thomas F. Tropea; Kenneth Marek; Tanya Simuni; Andrew Siderowf; Caroline Tanner; Thomas F. Tropea; Tatiana Foroud; Lana Chahine; Brit Mollenhauer; Kalpana Merchant; Douglas Galasko; Christopher Coffey; Kathleen Poston; Roseanne Dobkin; Ethan Brown; Roy Alcalay; Dan Weintraub; Emily Flagg; Kimberly Fabrizio; Susan Bressman; Cornelis Blauwendraat; Paola Casalin; Sonya Dumanis; Raymond James; Karl Kieburtz; Sneha Mantri; Werner Poewe; Michael Schwarzschild; John Seibyl; David Standaert; Sonja Jonsdottir; Claire Pauly; the Parkinson’s Progression Markers Initiative

doi:10.1002/ana.78230

Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI

Craig E. Stanley^*
, Kimberly Fabrizio
, Bridget A. McMahon
, Auldyn Matthews-McGee
, Cailey Fitzgerald
, Zeina Singh
, Nichole H. Rigby
, John Michael Talarico
, Ethan G. Brown
, Monica Korell
, Maggie McGuire Kuhl
, Christina Destro
, Nicola Pavese
, Alicia Garrido
, Brit Mollenhauer
, Sohini Chowdhury
, Kenneth Marek
, Caroline M. Tanner
, Thomas F. Tropea^*
, Kenneth Marek

Tanya Simuni, Andrew Siderowf, Caroline Tanner, Thomas F. Tropea^*, Tatiana Foroud, Lana Chahine, Brit Mollenhauer, Kalpana Merchant, Douglas Galasko, Christopher Coffey, Kathleen Poston, Roseanne Dobkin, Ethan Brown, Roy Alcalay, Dan Weintraub, Emily Flagg, Kimberly Fabrizio, Susan Bressman, Cornelis Blauwendraat, Paola Casalin, Sonya Dumanis, Raymond James, Karl Kieburtz, Sneha Mantri, Werner Poewe, Michael Schwarzschild, John Seibyl, David Standaert, Sonja Jonsdottir, Claire Pauly, the Parkinson’s Progression Markers Initiative

^*Corresponding author for this work

Transversal Translational Medicine

Research output: Contribution to journal › Editorial

Abstract

In the 15 years since Parkinson's Progression Markers Initiative (PPMI) launched, research conduct has advanced with broader connectivity, enabling virtual and hybrid methods for recruitment, engagement, education, and data collection. To meet evolving needs, PPMI created “myPPMI,” which has grown from an informational portal to a multi-country, participant-centered, virtual research environment integrating education, screening, e-consent, longitudinal non-motor and motor assessments, and biospecimen referral. Built on a secure, cloud-native architecture with daily analytics and a multi-tier support model, myPPMI enables precision recruitment, real-time eligibility matching, and standardized low-burden data capture across studies. The platform is designed to enable focused data collection from individuals or groups based on the data they have already provided. This strategy provides the tools to establish precise subsets of high interest that could be targeted for further data acquisition. Usability testing and rapid global scaling demonstrate a generalizable, decentralized framework for biomarker-driven, Parkinson's disease research. ANN NEUROL 2026.

Original language	English
Number of pages	8
Journal	Annals of Neurology
Early online date	21 Apr 2026
DOIs	https://doi.org/10.1002/ana.78230
Publication status	Published - 21 Apr 2026

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Stanley, C. E., Fabrizio, K., McMahon, B. A., Matthews-McGee, A., Fitzgerald, C., Singh, Z., Rigby, N. H., Talarico, J. M., Brown, E. G., Korell, M., McGuire Kuhl, M., Destro, C., Pavese, N., Garrido, A., Mollenhauer, B., Chowdhury, S., Marek, K., Tanner, C. M., Tropea, T. F., ... the Parkinson’s Progression Markers Initiative (2026). Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI. Annals of Neurology. https://doi.org/10.1002/ana.78230

@article{e9fe889daf714e7e89b55be24b60ce1e,

title = "Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI",

abstract = "In the 15 years since Parkinson's Progression Markers Initiative (PPMI) launched, research conduct has advanced with broader connectivity, enabling virtual and hybrid methods for recruitment, engagement, education, and data collection. To meet evolving needs, PPMI created {\textquotedblleft}myPPMI,{\textquotedblright} which has grown from an informational portal to a multi-country, participant-centered, virtual research environment integrating education, screening, e-consent, longitudinal non-motor and motor assessments, and biospecimen referral. Built on a secure, cloud-native architecture with daily analytics and a multi-tier support model, myPPMI enables precision recruitment, real-time eligibility matching, and standardized low-burden data capture across studies. The platform is designed to enable focused data collection from individuals or groups based on the data they have already provided. This strategy provides the tools to establish precise subsets of high interest that could be targeted for further data acquisition. Usability testing and rapid global scaling demonstrate a generalizable, decentralized framework for biomarker-driven, Parkinson's disease research. ANN NEUROL 2026.",

author = "Stanley, \{Craig E.\} and Kimberly Fabrizio and McMahon, \{Bridget A.\} and Auldyn Matthews-McGee and Cailey Fitzgerald and Zeina Singh and Rigby, \{Nichole H.\} and Talarico, \{John Michael\} and Brown, \{Ethan G.\} and Monica Korell and \{McGuire Kuhl\}, Maggie and Christina Destro and Nicola Pavese and Alicia Garrido and Brit Mollenhauer and Sohini Chowdhury and Kenneth Marek and Tanner, \{Caroline M.\} and Tropea, \{Thomas F.\} and Kenneth Marek and Tanya Simuni and Andrew Siderowf and Caroline Tanner and Tropea, \{Thomas F.\} and Tatiana Foroud and Lana Chahine and Brit Mollenhauer and Kalpana Merchant and Douglas Galasko and Christopher Coffey and Kathleen Poston and Roseanne Dobkin and Ethan Brown and Roy Alcalay and Dan Weintraub and Emily Flagg and Kimberly Fabrizio and Susan Bressman and Cornelis Blauwendraat and Paola Casalin and Sonya Dumanis and Raymond James and Karl Kieburtz and Sneha Mantri and Werner Poewe and Michael Schwarzschild and John Seibyl and David Standaert and Sonja Jonsdottir and Claire Pauly and \{the Parkinson{\textquoteright}s Progression Markers Initiative\}",

note = "Invited Editorial Publisher Copyright: {\textcopyright} 2026 American Neurological Association.",

year = "2026",

month = apr,

day = "21",

doi = "10.1002/ana.78230",

language = "English",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley \& Sons Inc.",

}

Stanley, CE, Fabrizio, K, McMahon, BA, Matthews-McGee, A, Fitzgerald, C, Singh, Z, Rigby, NH, Talarico, JM, Brown, EG, Korell, M, McGuire Kuhl, M, Destro, C, Pavese, N, Garrido, A, Mollenhauer, B, Chowdhury, S, Marek, K, Tanner, CM, Tropea, TF, Marek, K, Simuni, T, Siderowf, A, Tanner, C, Tropea, TF, Foroud, T, Chahine, L, Mollenhauer, B, Merchant, K, Galasko, D, Coffey, C, Poston, K, Dobkin, R, Brown, E, Alcalay, R, Weintraub, D, Flagg, E, Fabrizio, K, Bressman, S, Blauwendraat, C, Casalin, P, Dumanis, S, James, R, Kieburtz, K, Mantri, S, Poewe, W, Schwarzschild, M, Seibyl, J, Standaert, D, Jonsdottir, S , Pauly, C & the Parkinson’s Progression Markers Initiative 2026, 'Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI', Annals of Neurology. https://doi.org/10.1002/ana.78230

TY - JOUR

T1 - Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative

T2 - myPPMI

AU - Stanley, Craig E.

AU - Fabrizio, Kimberly

AU - McMahon, Bridget A.

AU - Matthews-McGee, Auldyn

AU - Fitzgerald, Cailey

AU - Singh, Zeina

AU - Rigby, Nichole H.

AU - Talarico, John Michael

AU - Brown, Ethan G.

AU - Korell, Monica

AU - McGuire Kuhl, Maggie

AU - Destro, Christina

AU - Pavese, Nicola

AU - Garrido, Alicia

AU - Mollenhauer, Brit

AU - Chowdhury, Sohini

AU - Marek, Kenneth

AU - Tanner, Caroline M.

AU - Tropea, Thomas F.

AU - Marek, Kenneth

AU - Simuni, Tanya

AU - Siderowf, Andrew

AU - Tanner, Caroline

AU - Tropea, Thomas F.

AU - Foroud, Tatiana

AU - Chahine, Lana

AU - Mollenhauer, Brit

AU - Merchant, Kalpana

AU - Galasko, Douglas

AU - Coffey, Christopher

AU - Poston, Kathleen

AU - Dobkin, Roseanne

AU - Brown, Ethan

AU - Alcalay, Roy

AU - Weintraub, Dan

AU - Flagg, Emily

AU - Fabrizio, Kimberly

AU - Bressman, Susan

AU - Blauwendraat, Cornelis

AU - Casalin, Paola

AU - Dumanis, Sonya

AU - James, Raymond

AU - Kieburtz, Karl

AU - Mantri, Sneha

AU - Poewe, Werner

AU - Schwarzschild, Michael

AU - Seibyl, John

AU - Standaert, David

AU - Jonsdottir, Sonja

AU - Pauly, Claire

AU - the Parkinson’s Progression Markers Initiative

PY - 2026/4/21

Y1 - 2026/4/21

N2 - In the 15 years since Parkinson's Progression Markers Initiative (PPMI) launched, research conduct has advanced with broader connectivity, enabling virtual and hybrid methods for recruitment, engagement, education, and data collection. To meet evolving needs, PPMI created “myPPMI,” which has grown from an informational portal to a multi-country, participant-centered, virtual research environment integrating education, screening, e-consent, longitudinal non-motor and motor assessments, and biospecimen referral. Built on a secure, cloud-native architecture with daily analytics and a multi-tier support model, myPPMI enables precision recruitment, real-time eligibility matching, and standardized low-burden data capture across studies. The platform is designed to enable focused data collection from individuals or groups based on the data they have already provided. This strategy provides the tools to establish precise subsets of high interest that could be targeted for further data acquisition. Usability testing and rapid global scaling demonstrate a generalizable, decentralized framework for biomarker-driven, Parkinson's disease research. ANN NEUROL 2026.

AB - In the 15 years since Parkinson's Progression Markers Initiative (PPMI) launched, research conduct has advanced with broader connectivity, enabling virtual and hybrid methods for recruitment, engagement, education, and data collection. To meet evolving needs, PPMI created “myPPMI,” which has grown from an informational portal to a multi-country, participant-centered, virtual research environment integrating education, screening, e-consent, longitudinal non-motor and motor assessments, and biospecimen referral. Built on a secure, cloud-native architecture with daily analytics and a multi-tier support model, myPPMI enables precision recruitment, real-time eligibility matching, and standardized low-burden data capture across studies. The platform is designed to enable focused data collection from individuals or groups based on the data they have already provided. This strategy provides the tools to establish precise subsets of high interest that could be targeted for further data acquisition. Usability testing and rapid global scaling demonstrate a generalizable, decentralized framework for biomarker-driven, Parkinson's disease research. ANN NEUROL 2026.

UR - https://www.scopus.com/pages/publications/105036721667

UR - https://pubmed.ncbi.nlm.nih.gov/42015362/

U2 - 10.1002/ana.78230

DO - 10.1002/ana.78230

M3 - Editorial

C2 - 42015362

AN - SCOPUS:105036721667

SN - 0364-5134

JO - Annals of Neurology

JF - Annals of Neurology

ER -

Developing a Virtual Research Environment in the Parkinson's Progression Markers Initiative: myPPMI

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